Guanylate Cyclase
Guanylate cyclase (guanylyl cyclase, GC), which catalyzes the formation of cGMP from GTP, exists in both the soluble and particulate fractions of cells. Guanylyl cyclases signal via the production of the second messenger cGMP.
The GC family consists of particulate GC (pGC) and a nitric oxide-activated soluble GC (sGC). Seven pGC isoforms have yet been found (pGC-A to pGC-G). pGCs are activated by binding of peptide ligands to their extracellular domains. sGC is a receptor for endogenous and exogenous nitric oxide and is activated several-fold upon its binding, constituting a core enzyme in the nitric oxide signal transduction pathway. cGMP generated by sGC is an important second messenger that regulates activity of several enzymes triggering such important physiologic reactions as vasodilation, smooth muscle relaxation and platelet aggregation.
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Guanylate Cyclase Inhibitors
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Guanylate Cyclase Activators
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Guanylate Cyclase Modulators
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Guanylate Cyclase Inducer
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Guanylate Cyclase Control
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Guanylate Cyclase Related Products (101)
Related Products (101)
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Antibodies (2)
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Mosliciguat
0 ImagesCat. No.: HY-137446CAS No.: 2231749-54-3Synonyms: BAY 1237592Mosliciguat (BAY 1237592) is an apo-soluble guanylate cyclase activator. Mosliciguat improves cardiopulmonary circulation, reduces pulmonary arterial pressure in animal models, and its efficacy is enhanced under oxidative stress conditions. Mosliciguat exerts a bronchodilatory effect in a rat model of acetylcholine-induced bronchoconstriction. Mosliciguat can be used for research on pulmonary arterial hypertension.
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sGC activator 1
0 ImagesCat. No.: HY-158146CAS No.: 2101645-33-2sGC activator 1 (example 10B) is an activator of soluble guanylate cyclase (SGC).
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RIG 200
0 ImagesCat. No.: HY-107000CAS No.: 202656-49-3RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus.
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KMUP-1
0 ImagesCat. No.: HY-129670CAS No.: 81996-46-5KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC). KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study.
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UA2239
0 ImagesCat. No.: HY-179656CAS No.: 2455422-89-4UA2239 is an antimalarial agent and acyclic nucleoside phosphonate. UA2239 disrupts the essential cGMP-dependent egress pathway by decreasing cGMP levels. UA2239 targets guanylyl cyclase α. UA2239 demonstrates rapid and irreversible inhibitory effects on Plasmodium parasites.
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sGC activator 2
0 ImagesCat. No.: HY-168341sGC activator 2 (Compound 16a) is an activator for soluble guanylate cyclase (sGC), that promotes the cGMP production and exhibits vascular protective and anti-inflammatory activities.
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TNP-GTP tetrasodium
0 ImagesCat. No.: HY-137609ASynonyms: TNP-Guanosine 5'-triphosphate tetrasodiumTNP-GTP tetrasodium is a fluorescently labeled GTP (HY-113225) derivative. TNP-GTP tetrasodium can inhibit glutamate dehydrogenase (Ki = 2.7 μM). TNP-GTP tetrasodium is an antagonist of the purinergic P2X2 and P2X2/3 receptors with IC50 values of 0.4 and 1.2 nM, respectively. TNP-GTP tetrasodium also inhibit rat soluble guanylyl cyclase (Ki = 11 nM).
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Nurandociguatum
0 ImagesCat. No.: HY-159523CAS No.: 2781965-75-9Synonyms: NurandociguatNurandociguatum (Nurandociguat) is a guanylate cyclase activator.
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S-3448
0 ImagesCat. No.: HY-124074CAS No.: 254877-04-8S-3448 is a derivative of Ataciguat (HY-17500). S-3448 is a Soluble guanylate cyclase (sGC) agonist. S-3448 activates both the haem-containing and the haem-deficient form of sGC without depending on NO and heme. S-3448 can be used for cardiovascular diseases such as arterial hypertension and pulmonary hypertension research.
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SGC agonist 1
0 ImagesCat. No.: HY-142697CAS No.: 1426309-31-0SGC agonist 1 is a potent agonist of soluble guanylate cyclase (SGC). SGC agonist 1 improves solubility combined with high cell permeability. SGC agonist 1 has the potential for the research of cardiovascular disease (extracted from patent WO2016030354A1, compound 18A).
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Methylene Blue Staining Solution (1%)
0 ImagesCat. No.: HY-DY2050Methylene Blue Staining Solution (1%) (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene Blue Staining Solution (1%) is a vasopressor and is often used as a dye in several medical procedures. Methylene Blue Staining Solution (1%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene Blue Staining Solution (1%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene Blue Staining Solution (1%) is a Tau aggregation inhibitor. Methylene Blue Staining Solution (1%) is a photosensitizer and redox agent. Methylene Blue Staining Solution (1%) reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.
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CFM 1571
0 ImagesCat. No.: HY-135451CAS No.: 268725-86-6CFM 1571 is a soluble guanylyl cyclase (sGC) activator with an IC50 of ~5.5 μM. CFM 1571 activates sGC in a NO-independent manner and exerts a synergistic effect with NO. CFM 1571 inhibits platelet aggregation.
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GSK2181236A
0 ImagesCat. No.: HY-119081CAS No.: 1160426-89-0GSK2181236A is a NO-insensitive soluble guanylate cyclase (sGC) activator. GSK2181236A can dilate blood vessels, decrease mean arterial pressure and attenuate the development of cardiac hypertrophy. GSK2181236A can be used for the research of cardiovascular disease, such as hypertension.
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LOXL2/sGC modulator-2
0 ImagesCat. No.: HY-180585LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension .
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(4-Acetamidocyclohexyl) nitrate
0 ImagesCat. No.: HY-100295CAS No.: 137213-91-3Synonyms: BM121307(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator.
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SGC stimulator 2
0 ImagesCat. No.: HY-187209CAS No.: 1350852-88-8SGC stimulator 2 is an orally active soluble guanylyl cyclase (sGC) stimulator with an EC50 of 44 nM. SGC stimulator 2 exhibits inhibitory activity against the CB2 receptor, with an IC50 of 2.7 μM. SGC stimulator 2 activates native (Fe2+) sGC in a heme-dependent manner. SGC stimulator 2 produces sustained hypotensive effects in animal models. SGC stimulator 2 can be used for the research of hypertension.
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Guanylin (mouse, rat)
0 ImagesCat. No.: HY-P5077CAS No.: 145257-03-0Guanylin (mouse, rat), a petide, is composed of 15 amino acids. Guanylin (mouse, rat) is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) can be used for the research of diarrhea.
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Antihypertensive agent 7
0 ImagesCat. No.: HY-184303Antihypertensive agent 7 is a vasodilator. Antihypertensive agent 7 acts on vascular endothelial cells to activate the PI3K/AKT signaling axis, increase phosphorylated eNOS, release NO, activate the sGC/cGMP pathway in smooth muscle cells, and synergistically activate multiple K+ channels in vascular smooth muscle (Kir/Kv/KCa/KATP, thereby inducing endothelium-dependent vasodilation. Antihypertensive agent 7 can be used in the research of hypertension.
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ODQ (Standard)
0 ImagesODQ (Standard) is the analytical standard of ODQ. This product is intended for research and analytical applications. ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.
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Riociguat (Standard)
0 ImagesSynonyms: BAY 632521 (Standard)Riociguat (Standard) is the analytical standard of Riociguat. This product is intended for research and analytical applications. Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
