2. Vías de señalización
  3. Protein Tyrosine Kinase/RTK
  4. IGF-1R
  5. IGF-1R Antagonist

IGF-1R Antagonist

IGF-1R Antagonists (4):

Cat. No. Nombre del producto Efecto Pureza
  • HY-142812
    GRK6-IN-1
    		Antagonist 99.61%
    GRK6-IN-1 (Compound 18) is the inhibitor for G protein-coupled receptorkinase 6 (GRK6) with an IC50 of 3.8-8 nM. GRK6-IN-1 also inhibits GRK7, GRK5, GRK4 and GRK1 with IC50s of 6.4, 12, 22 and 52 nM, respectively. GRK6-IN-1 has the potential for the research of multiple myeloma.
  • HY-P99274
    Xentuzumab
    		Antagonist 99.71%
    Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a human monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation.
  • HY-P990084
    Veligrotug
    		Antagonist 99.25%
    Veligrotug (AVE1642) is a selective, fully human IGF-1R antagonist antibody with a Kd value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease.
  • HY-P991042
    Anti-IGFBP2 Antibody (M14)
    		Antagonist ≥99.0%
    Anti-IGFBP2 Antibody (M14) is an human anti-IGFBP2 monoclonal inhibitory antibody, which binds IGFBP2 with high affinity and blocks its binding with IGF1. Anti-IGFBP2 Antibody (M14) inhibits human endothelial cell recruitment, thus blocks the tumor progression of human metastatic cancer.