MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
References:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
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MMP Related Products (441)
Related Products (441)
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Histatin 5 TFA
0 ImagesCat. No.: HY-P0273APurity: 99.98%Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
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Ginsenoside F4
0 ImagesGinsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues.
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Doxycycline-d3 (hyclate) (major)
0 ImagesCat. No.: HY-N0565S1Doxycycline-d3 hyclate (major) is the deuterium labeled Doxycycline hyclate (HY-N0565B). Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
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Mmp9 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08558Mmp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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MMP9 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08557MMP9 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Highly purified Type XI collagen, from porcine articular cartilage
0 ImagesCat. No.: HY-NP126Synonyms: Porcine Type XI collagen, immunization gradeHighly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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Edaravone-d5
0 ImagesSynonyms: MCI-186-d5Edaravone-d5 is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
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Palmitoyl tripeptide-5
0 ImagesCat. No.: HY-P5250CAS No.: 623172-55-4Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
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Methylisothiazolinone hydrochloride
0 ImagesMethylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
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Sotetsuflavone
0 ImagesSotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits phosphorylation of PI3K, Akt, mTOR, JNK, and p38 MAPK; modulates expression of Cyclin D1, CDK4, Bcl-2, Bax, cleaved caspases 3/9, MMP-9, TGF-β, STAT3, and β-catenin. Sotetsuflavone induces G0/G1 cell cycle arrest, apoptosis, autophagy, and intracellular ROS elevation, inhibits cancer cell proliferation. Sotetsuflavone inhibits tumor growth in mouse tumor xenograft models. Sotetsuflavone can be used for the research of non-small cell lung cancer and Crohn’s disease.
