MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
Références:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
-
MMP Produits associés (441)
Produits associés (441)
-
Abametapir (Standard)
0 ImagesAbametapir (Standard) is the analytical standard of Abametapir. This product is intended for research and analytical applications. Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse.
-
TAPI-2 (Standard)
0 ImagesCat. No.: HY-100211RCAS No.: 187034-31-7Synonyms: TNF Protease Inhibitor 2 (Standard)TAPI-2 (Standard) is the analytical standard of TAPI-2 (HY-100211). This product is intended for research and analytical applications. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV.
-
4-Epianhydrochlortetracycline hydrochloride
0 ImagesCat. No.: HY-120715CAS No.: 158018-53-24-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases.
-
JNJ0966 (Standard)
0 ImagesCat. No.: HY-103482RCAS No.: 315705-75-0
-
PNU-248686A
0 ImagesCat. No.: HY-19422CAS No.: 341498-89-3PNU-248686A is a novel matrix metalloproteinase (MMP) inhibitor.
-
BR351 precursor
0 ImagesCat. No.: HY-43586CAS No.: 960113-89-7BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively.
-
NRMA-10
0 ImagesCat. No.: HY-164504CAS No.: 2375659-17-7NRMA-10, an amide prodrug, is a brain-penetrant nuclear receptor modulator. NRMA-10 increases brain expression of Adam10. NRMA-10 preferres distribution to the CNS compared to the periphery. NRMA-10 can be used for the study of central nervous system (CNS) disorders.
-
proMMP-9 inhibitor-3c
0 ImagesCat. No.: HY-122585CAS No.: 2138321-18-1proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX).
-
Kuwanon G (Standard)
0 ImagesCat. No.: HY-N4247RCAS No.: 75629-19-5Kuwanon G (Standard) is the analytical standard of Kuwanon G (HY-N4247). This product is intended for research and analytical applications. Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.
-
GI254023X (Standard)
0 ImagesCat. No.: HY-19956RCAS No.: 260264-93-5Synonyms: GI4023 (Standard); SRI028594 (Standard)
-
Aderbasib-d3
0 ImagesCat. No.: HY-W703549Synonyms: INCB007839-d3; INCB7839-d3Aderbasib-d3 (INCB007839-d3) is deuterium labeled Aderbasib. Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+?breast cancer, gliomas, et al.
-
5-Methoxytryptophol (Standard)
0 Images5-Methoxytryptophol (Standard) is the analytical standard of 5-Methoxytryptophol. This product is intended for research and analytical applications. 5-Methoxytryptophol is a 5-methoxyindole alcohol structurally homologous to Melatonin (HY-B0075). It is secreted by the mammalian pineal gland and exhibits an inverse circadian rhythm. 5-Methoxytryptophol regulates bone metabolism by activating the ERK1/2 pathway. It reduces the levels of pro-inflammatory cytokines TNF-α and IL-1β, as well as proteolytic enzymes MMP-1 and MMP-2, in serum and dental pulp tissues, thereby ameliorating acute pulpitis. 5-Methoxytryptophol induces rapid sleep in mice, while high doses cause respiratory depression and death. 5-Methoxytryptophol. 5-Methoxytryptophol can be used in studies related to acute pulpitis, hypnosis, and bone metabolism.
-
Hippuric acid-13C6
0 ImagesCat. No.: HY-W747703CAS No.: 1163160-18-6Synonyms: Benzoylglycine-13C6Hippuric acid-13C6 (Benzoylglycine-13C6) is 13C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research. .
-
LQB-118
0 ImagesCat. No.: HY-124068CAS No.: 1219104-20-7LQB-118 is an orally active compound derived from sandalwood. LQB-118 can inhibit the migration of glioblastoma cells and induce cell death. LQB-118 can suppress the migration and invasion of prostate cancer cells by regulating the AKT/GSK3β pathway and the expression of the MMP-9/reck genes. LQB-118 can also inhibit yeast polysaccharide-induced inflammation both in vivo and in vitro. Additionally, LQB-118 selectively induces ROS-triggered and mitochondrial-dependent apoptosis in Leishmania amazonensis. LQB-118 can be used in studies related to inflammation, infections, and cancer diseases.
-
Vicenin 3 (Standard)
0 ImagesCat. No.: HY-N4090RCAS No.: 59914-91-9Vicenin 3 (Standard) is the analytical standard of Vicenin 3. Vicenin 3 is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 46.91 μM) that can be isolated from the aerial parts of Desmodium styracifolium. Vicenin 3 ameliorates IL-1β-induced extracellular matrix degradation in SW1353 chondrocytes by regulating the MAPK pathway. Vicenin 3 can be used for the study of osteoarthritis (OA) and hypertension.
-
Imidapril hydrochloride (Standard)
0 ImagesSynonyms: TA-6366 (Standard)Imidapril (hydrochloride) (Standard) is the analytical standard of Imidapril (hydrochloride). This product is intended for research and analytical applications. Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.
-
(S,S)-TAPI-0
0 ImagesCat. No.: HY-136885CAS No.: 143457-40-3
-
GW280264X (Standard)
0 ImagesCat. No.: HY-115670RCAS No.: 866924-39-2GW280264X (Standard) is the analytical standard of GW280264X (HY-115670). This product is intended for research and analytical applications. GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.
-
Pyridoxatin
0 ImagesCat. No.: HY-125568CAS No.: 135529-30-5Pyridoxatin is a free radical scavenger of microbial origin. Pyridoxatin is isolated from a fungus culture identified as Acremonium sp. BX86. Pyridoxatin inhibits lipid peroxidation induced by free radicals in rat liver microsomes free from vitamin E.
-
C-telopeptide
0 ImagesCat. No.: HY-P0284CAS No.: 162929-64-8C-telopeptide is a cross-linked peptide of type I collagen that is released during bone resorption and correlates with bone mineral density (BMD). C-telopeptide can be used in studies related to postmenopausal osteoporosis.
