Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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N6-iso-Propyladenosine
0 ImagesCat. No.: HY-152608CAS No.: 17270-23-4N6-iso-Propyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-N-(3-methyl-2-buten-1-yl)adenosine
0 ImagesCat. No.: HY-152564CAS No.: 16051-64-22-Amino-N-(3-methyl-2-buten-1-yl)adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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2′-Deoxy-2′-fluoro-5-methoxy-arabinouridine
0 ImagesCat. No.: HY-152674CAS No.: 2305415-76-1
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4α-Methyl-5α-ergosta-8,14,24(28)-trien-3β-ol
0 ImagesCat. No.: HY-180650CAS No.: 74635-33-94α-Methyl-5α-ergosta-8,14,24(28)-trien-3β-ol is a nucleoside metabolite.
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1,4-Anhydro-2,3-O-isopropylidene-5-O-t-butyldiphenylsilyl-4-thio-D-ribitol
0 ImagesCat. No.: HY-154369CAS No.: 1320269-77-91,4-Anhydro-2,3-O-isopropylidene-5-O-t-butyldiphenylsilyl-4-thio-D-ribitol is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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trans-2,3-Dihydroxycinnamate
0 ImagesCat. No.: HY-180639CAS No.: 38481-04-8trans-2,3-Dihydroxycinnamate, a derivative of Cinnamic acid (HY-N0610A), is a metabolite of cannabidiol. trans-2,3-Dihydroxycinnamate possesses antioxidizing activity.
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DMTr-TNA-C(Bz)-amidite
0 ImagesCat. No.: HY-154530CAS No.: 325683-96-3DMTr-TNA-C(Bz)-amidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-3’-fluoro-N1-methyluridine
0 ImagesCat. No.: HY-154291CAS No.: 3047198-16-03’-Deoxy-3’-fluoro-N1-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Methyl-2-methyl thioadenosine
0 ImagesN6-Methyl-2-methyl thioadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro-xylo-guanosine
0 ImagesCat. No.: HY-152373CAS No.: 2389988-56-97,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro-xylo-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7,8-Dihydro-8-oxo-7-propargyl-3’-deoxy-3’-fluoro-xylo-guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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9-(2,3,5-Tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purin-2-amine
0 ImagesCat. No.: HY-154653CAS No.: 1345969-99-49-(2,3,5-Tri-O-benzoyl-2-C-methyl-β-D-ribofuranosyl)-9H-purin-2-amine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5'-O-DMT-N6-ibu-dA
0 Images5'-O-DMT-N6-ibu-dA can be used in the synthesis of oligodeoxyribonucleotides.
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2'-Deoxyadenosine-15N1
0 ImagesCat. No.: HY-W745905CAS No.: 106568-85-82'-Deoxyadenosine-15N1 is the 15N-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite
0 ImagesCat. No.: HY-154351CAS No.: 171486-61-6N2-iBu-5’-O-DMTr-2’-O-propargylguanosine-3’-CED-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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2-Amino-N,N-dimethyl-2′-C-methyladenosine
0 ImagesCat. No.: HY-152723CAS No.: 1336975-57-52-Amino-N,N-dimethyl-2′-C-methyladenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Nyasicoside
0 ImagesCat. No.: HY-N3167CAS No.: 111518-94-6Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig.
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8-Chloro-2’-O-methyl adenosine
0 ImagesCat. No.: HY-152635CAS No.: 634207-55-98-Chloro-2’-O-methyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-(4,4’-Dimethoxytrityl)-3’-O-t-butyldimethylsilyl adenosine
0 ImagesCat. No.: HY-W560806CAS No.: 81794-12-95’-O-(4,4’-Dimethoxytrityl)-3’-O-t-butyldimethylsilyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
