Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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5-Methyl-4-thiouridine
0 ImagesCat. No.: HY-152505CAS No.: 49555-43-35-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’,3’,5’-Tri-O-benzoyl-2’-β-C-methyl-5-methyl uridine
0 ImagesCat. No.: HY-154144CAS No.: 957535-53-4
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3′-Deoxy-3′-methylcytidine
0 ImagesCat. No.: HY-152731CAS No.: 444020-09-13′-Deoxy-3′-methylcytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-Deoxy-5-methyluridine
0 ImagesCat. No.: HY-154491CAS No.: 56971-08-55’-Deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Naphthyl-β-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine
0 ImagesCat. No.: HY-152801CAS No.: 2095417-03-95-Naphthyl-β-methylaminocarbony-3’-O-acetyl-2’-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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1-(b-D-Xylofuranosyl)-5-trifluoromethyluracil
0 ImagesCat. No.: HY-1541301-(b-D-Xylofuranosyl)-5-trifluoromethyluracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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15-Hydroxy-5,6-oxido-7,9,11,13-eicosatetraenoic acid
0 ImagesCat. No.: HY-180655CAS No.: 94235-42-4(5,6)-Epoxytetraene is a precursor of the trapping product in the biosynthesis of lipoxins in human leukocytes.
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2’-Chloro-N6-benzyl adenosine
0 ImagesCat. No.: HY-154597CAS No.: 23558-62-52’-Chloro-N6-benzyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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3’-Deoxy-N1-Methyl inosine
0 ImagesCat. No.: HY-1542923’-Deoxy-N1-Methyl inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7-n-Propyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
0 ImagesCat. No.: HY-152331CAS No.: 2389988-44-57-n-Propyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Pseudouridine-O18
0 ImagesCat. No.: HY-113061SPseudouridine-18O is the 18O labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation.
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N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine
![N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine](https://file.medchemexpress.com/product_pic/hy-154336.gif "Click to View N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine Product Detail")
0 ImagesCat. No.: HY-154336CAS No.: 937205-20-4N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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2',3,5'-Tri-O-benzoyl-4'-thiouridine
0 ImagesCat. No.: HY-154646CAS No.: 2072145-30-12’,3’,5’-Tri-O-benzoyl-4’-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-MOE-5MeU-2’-phosphoramidite
0 ImagesCat. No.: HY-154545CAS No.: 256223-93-53’-O-MOE-5MeU-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-N4-ethyl-5-methylcytidine
0 ImagesCat. No.: HY-154473CAS No.: 25406-43-32’-Deoxy-N4-ethyl-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N1-Methyl-2’-beta-C-methyl guanosine
0 ImagesCat. No.: HY-152563N1-Methyl-2’-beta-C-methyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-N1-methylguanosine
0 ImagesCat. No.: HY-1525933’-Deoxy-N1-methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-methyl-2-thiouridine
0 ImagesCat. No.: HY-152379CAS No.: 2305416-19-53’-Deoxy-methyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-6-chloro-9-[(2,3,5-tri-O-benzoyl-2-C-Methyl-beta-D-ribofuranosyl)]-9H-purine
![2-Amino-6-chloro-9-[(2,3,5-tri-O-benzoyl-2-C-Methyl-beta-D-ribofuranosyl)]-9H-purine](https://file.medchemexpress.com/product_pic/hy-w069715.gif "Click to View 2-Amino-6-chloro-9-[(2,3,5-tri-O-benzoyl-2-C-Methyl-beta-D-ribofuranosyl)]-9H-purine Product Detail")
0 ImagesCat. No.: HY-W069715CAS No.: 641571-44-02-Amino-6-chloro-9-[(2,3,5-tri-O-benzoyl-2-C-Methyl-beta-D-ribofuranosyl)]-9H-purine dibenzoate is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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7-Ethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
0 ImagesCat. No.: HY-152328CAS No.: 2389988-43-47-Ethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
