Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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N6-Methyl-2’-beta-C-ethynyl adenosine
0 ImagesCat. No.: HY-152627N6-Methyl-2’-beta-C-ethynyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. N6-Methyl-2’-beta-C-ethynyl adenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Tegafur-13C,15N2
0 ImagesCat. No.: HY-W777033CAS No.: 1189456-27-6Synonyms: FT 207-13C,15N2; NSC 148958-13C,15N2
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5-(2-Azidoethyl)uridine
0 ImagesCat. No.: HY-1542565-(2-Azidoethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5-(2-Azidoethyl)uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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3’-Azido-3’-deoxy-2-thiouridine
0 ImagesCat. No.: HY-152353CAS No.: 2305416-00-43’-Azido-3’-deoxy-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-2-thiouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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5’-O-Triphenylmethyl-2’-deoxyuridine
0 ImagesCat. No.: HY-154239CAS No.: 14270-73-65’-O-Triphenylmethyl-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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TLR7 agonist 13
0 ImagesCat. No.: HY-154361CAS No.: 2389988-70-7TLR7 agonist 13 is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). TLR7 agonist 13 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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2'-Deoxy-5-hydroxymethyl-CTP
0 ImagesCat. No.: HY-180700CAS No.: 10097-59-32'-Deoxy-5-hydroxymethyl-CTP is a nucleoside metabolite.
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5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine
0 ImagesCat. No.: HY-153059CAS No.: 163496-07-95-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine is a nucleoside compound.
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N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine
0 ImagesCat. No.: HY-154024CAS No.: 2305416-18-4N4-Benzoyl-2’-O-(2-methoxyethyl)cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7-Methylguanosine-13C,d3 iodide
0 ImagesCat. No.: HY-122524AS7-Methylguanosine-13C,d3 iodide is the 13C- and deuterium labeled 7-Methylguanosine iodide (HY-122524A). 7-Methylguanosine iodide is an iodide of 7-Methylguanosine (HY-122524). 7-Methylguanosine is a modified nucleoside widely present in various RNAs and a key metabolite of the 5'-cap structure of eukaryotic mRNA. 7-Methylguanosine plays important roles in stabilizing RNA structures, regulating translation, and other aspects.
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8-Hydroxy-xyloguanosine
0 ImagesCat. No.: HY-152375CAS No.: 2390368-04-28-Hydroxy-xyloguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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dTPNPP
0 ImagesCat. No.: HY-155936CAS No.: 141171-14-4Synonyms: Thymidine 5'-(α,β-imido)triphosphatedTPNPP is an α,β-iminotriphosphate analog of dTTP, with an imino group in the α,β-phosphate bridge. dTPNPP is used in studies related to nucleotide analogs and phosphoryl transfer.
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IBU-DC Phosphoramidite
0 ImagesCat. No.: HY-138584CAS No.: 110522-84-4IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.
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2’-β-C-Ethynyladenosine
0 ImagesCat. No.: HY-152475CAS No.: 640725-76-42’-β-C-Ethynyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Uridine-5-oxyacetic acid
0 ImagesCat. No.: HY-152594CAS No.: 28144-25-4Uridine-5-oxyacetic acid is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5'-Deoxyadenosine (Standard)
0 ImagesCat. No.: HY-113291RCAS No.: 4754-39-65'-Deoxyadenosine (Standard) is the analytical standard of 5'-Deoxyadenosine (HY-113291). This product is intended for research and analytical applications. 5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase.
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5-Hydroxyindolepyruvate
0 ImagesCat. No.: HY-180737CAS No.: 13094-31-05-Hydroxyindolepyruvate is a nucleoside metabolite.
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4′,5′-Didehydro-5′-deoxy-2′-O-methyluridine
0 ImagesCat. No.: HY-154307CAS No.: 1848223-48-24′,5′-Didehydro-5′-deoxy-2′-O-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Methoxy-4-thiouridine
0 ImagesCat. No.: HY-152540CAS No.: 37805-89-35-Methoxy-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine
0 ImagesCat. No.: HY-154148CAS No.: 25775-85-3N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
