2’-β-C-Ethynyladenosine
2’-β-C-Ethynyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-β-C-Ethynyladenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 640725-76-4
- Formula: C12H13N5O4
- Molecular Weight:291.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
40 μM
Compound: 11
|
Cytotoxicity against human A549 cells assessed as intracellular ATP level by Celltiter-Glo luminescent assay
Cytotoxicity against human A549 cells assessed as intracellular ATP level by Celltiter-Glo luminescent assay
|
[PMID: 20457821] |
| A549 | EC50 |
1.41 μM
Compound: 11
|
Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells assessed as level of E protein after 48 hrs by ELISA
Antiviral activity against at 0.3 MOI Dengue virus 2 infected in human A549 cells assessed as level of E protein after 48 hrs by ELISA
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[PMID: 20457821] |
Chemical Information
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CAS No. 640725-76-4
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Molecular Weight 291.26
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Formula C12H13N5O4
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SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@]1(C#C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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