PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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tert-Butyl ((3-(aminomethyl)cyclobutyl)methyl)carbamate
0 ImagesCat. No.: HY-W056066CAS No.: 1363382-06-2Synonyms: 3-Aminomethyl-1-(boc-aminomethyl)cyclobutane
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N-(Azido-PEG2)-N-Fluorescein-PEG3-acid
0 ImagesCat. No.: HY-140544CAS No.: 2086689-04-3N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG2)-N-Boc-PEG3-acid
0 ImagesCat. No.: HY-140524CAS No.: 2086689-01-0N-(Azido-PEG2)-N-Boc-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG1-CH2COO-Cl
0 ImagesCat. No.: HY-130984CAS No.: 79598-49-5Azido-PEG1-CH2COO-Cl (compound 43a) is an alkyl/ether-based PROTAC linker. Azido-PEG1-CH2COO-Cl can be used in the synthesis of PROTAC BRD4 Degrader-1 (HY-133131). Azido-PEG1-CH2COO-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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t-Boc-Aminooxy-PEG3-alcohol
0 ImagesCat. No.: HY-140422CAS No.: 252378-66-8
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PEG3-bis(phosphonic acid diethyl ester)
0 ImagesCat. No.: HY-141321CAS No.: 1807539-03-2
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Boc-N-Amido-PEG2-C2-azide
0 ImagesCat. No.: HY-140834CAS No.: 950683-55-3Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-N-Amido-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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2-[(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-yl]ethan-1-ol
![2-[(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-yl]ethan-1-ol](https://file.medchemexpress.com/product_pic/hy-w763939.gif "Click to View 2-[(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-yl]ethan-1-ol Product Detail")
0 ImagesCat. No.: HY-W763939CAS No.: 1354427-47-6
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Aminooxy-PEG3-methyl ester
0 ImagesCat. No.: HY-140404CAS No.: 2086689-03-2
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Boc-NH-PEG3-sulfonic acid
0 ImagesCat. No.: HY-140172CAS No.: 1817735-32-2
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N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester
0 ImagesCat. No.: HY-140564CAS No.: 2112732-03-1N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG3-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Boc-PEG8-Boc
0 ImagesCat. No.: HY-138335CAS No.: 1432970-18-7
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Thiol-PEG3-NHBoc
0 ImagesCat. No.: HY-138759CAS No.: 1895922-68-5
