-
ROR Related Products (98)
Related Products (98)
-
RORγt modulator 2
0 ImagesCat. No.: HY-142935CAS No.: 2247083-47-0RORγt modulator 2 (Compound 21) is a modulator of retinoid-related orphan receptor γt (RORγt) with the IC50 of <50 nM. RORγt modulator 2 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
-
Methyl-3β-hydroxycholenate
0 ImagesCat. No.: HY-100084CAS No.: 20231-57-6Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.
-
RORγt inverse agonist 28
0 ImagesCat. No.: HY-142703CAS No.: 2741870-21-1RORγt inverse agonist 28 is a potent reverse agonist of RORγt. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 6) .
-
RORγt/DHODH-IN-3
0 ImagesCat. No.: HY-142847CAS No.: 2764662-16-8RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC50s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity.
-
Rorc Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12133Rorc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rorc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Rora Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12127Rora Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rora gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
RORγt/DHODH-IN-2
0 ImagesCat. No.: HY-142834CAS No.: 2641758-86-1RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research.
-
Allolithocholic acid (Standard)
0 ImagesCat. No.: HY-143712RCAS No.: 2276-94-0Allolithocholic acid (Standard) is the analytical standard of Allolithocholic acid (HY-143712). This product is intended for research and analytical applications. Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
-
RORγ inverse agonist 2
0 ImagesCat. No.: HY-175490CAS No.: 1242610-59-8
-
JNJ-54119936
0 ImagesCat. No.: HY-148237CAS No.: 1599531-55-1JNJ-54119936, a chemical probe, is a RORγ (RORc) inverse agonist (Kd=5.3 nM).
-
RORγt modulator 3
0 ImagesCat. No.: HY-142936CAS No.: 2230877-38-8RORγt modulator 3 (Compound 23) is a modulator of retinoid-related orphan receptor γt (RORγt). RORγt modulator 3 can be used for the research of RORyt mediated diseases such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
-
TF-S14
0 ImagesCat. No.: HY-162490CAS No.: 2425563-60-4
-
PROTAC ROR1 degrader-1
0 ImagesCat. No.: HY-170995PROTAC ROR1 degrader-1 is a ROR1 PROTAC degrader with DC50 values of 40.88 nM (NCI-H23), 69.0 nM (NCI-H460), 83.35 nM (NCI-H1299) and 42.07 nM (NCI-H1975), respectively. PROTAC ROR1 degrader-1 inhibits the proliferation of lung cancer cells and induces apoptosis. PROTAC ROR1 degrader-1 can be used in research related to non-small cell lung cancer.
-
RORB Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS12129RORB Human Pre-designed siRNA Set A contains three designed siRNAs for RORB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
RORγt inverse agonist 31
0 ImagesCat. No.: HY-155548CAS No.: 3048344-59-5RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice.
-
BL20-MMAE
0 ImagesCat. No.: HY-177109CAS No.: 2765612-38-0BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody with the Auristatin payload MMAE (HY-15162) via a BL20 linker.
-
Allolithocholic Acid-d4
0 ImagesCat. No.: HY-143712S1Synonyms: 3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid (HY-143712). Allolithocholic acid is an orally active metabolite of Lithocholic acid (HY-B0172). Allolithocholic acid is a dual GPBAR1 agonist (EC50 = 2.7 μM) and RORγt inverse agonist (IC50 = 3.4 μM). Allolithocholic acid modulates immune and metabolic pathways, regulates immune cell polarization, prevents M1 macrophage and Th17 CD4 cell polarization. Allolithocholic acid improves insulin sensitivity, reduces liver lipid accumulation, reverses liver immunological, inflammatory and metabolic signaling dysregulation, restores bile acid homeostasis, adipose tissue histopathology/function, and intestinal microbiota composition, modulates intestinal immunity. Allolithocholic acid can be used for the researches of cancer, inflammayion, immunology and metabolic disease.
-
huXBR1-402
0 ImagesCat. No.: HY-P992376Synonyms: NBE-002 AntibodyhuXBR1-402 (NBE-002 Antibody) is a high-affinity (Kd=5.8 nM) humanized chimeric rabbit/human monoclonal antibody that targets ROR1. huXBR1-402 specifically binds to the Ig/Fz domain epitope of human ROR1, directly inhibits the proliferation of ROR1-positive tumor cells and induces apoptosis of leukemia cells (apoptosis).
-
RORγt agonist 4
0 ImagesCat. No.: HY-160021CAS No.: 2241769-59-3RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma.
