2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. RORγt inverse agonist 31

RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice.

For research use only. We do not sell to patients.

RORγt inverse agonist 31 Chemical Structure

RORγt inverse agonist 31 Chemical Structure

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RORγt inverse agonist 31 Related Antibodies

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Description

RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice[1].

IC50 & Target

IC50: 0.428 μM (RORγt)[1]
Molecular Weight

555.36

Formula

C23H15Cl2F3N4O3S
SMILES

FC(C1=CC=C(C2=NC(NC3=CC=C(S(=O)(C)=O)C=C3)=NC(OC4=C(Cl)C=CC=C4Cl)=N2)C=C1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RORγt inverse agonist 31 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RORγt inverse agonist 31RORγt inverse agonist31RORγt inverse agonist-31RORRAR-related orphan receptorImiquimodpsoriasisInhibitorinhibitorinhibit

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RORγt inverse agonist 31
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