Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
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Ser/Thr Protease Inhibitors
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Ser/Thr Protease Agonist
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Ser/Thr Protease Activators
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Ser/Thr Protease Modulator
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Ser/Thr Protease Degrader
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Ser/Thr Protease Control
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Ser/Thr Protease Substrates
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Ser/Thr Protease Ligands
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Ser/Thr Protease Related Products (378)
Related Products (378)
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Antibodies (11)
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UAMC-00050 free base
0 ImagesCat. No.: HY-151611ACAS No.: 934622-26-1UAMC-00050 free base is a potent trypsin-like serine protease inhibitor. UAMC-00050 free base can be used in research of dry eye syndrome and ocular inflammation.
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CU-2010
0 ImagesCat. No.: HY-182406CAS No.: 1021707-76-5CU-2010 is a Serine protease inhibitor. In canine models, CU-2010 reduces blood loss after cardiac surgery in a dose-dependent manner and improves post-ischemic recovery.
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DCLK1-IN-6
0 ImagesCat. No.: HY-178776DCLK1-IN-6 (Compound 12n) is a Doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 58 nM. DCLK1-IN-6 significantly inhibits DCLK1 enzyme activity and its mediated inflammatory pathway. DCLK1-IN-6 has remarkable anti-inflammatory activity and significantly alleviates symptoms in acute lung injury (ALI) and sepsis mouse models. DCLK1-IN-6 can be used for acute inflammation diseases research.
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D-Val-Phe-Lys-CMK
0 ImagesCat. No.: HY-P10095CAS No.: 75590-17-9Synonyms: D-Val-Phe-Lys Chloromethyl ketoneD-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity.
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FOY 251 (Standard)
0 ImagesCat. No.: HY-19727ARCAS No.: 71079-09-9
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Aureoquinone
0 ImagesCat. No.: HY-N13896CAS No.: 321658-21-3
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Leupeptin hydrochloride
0 ImagesCat. No.: HY-183478CAS No.: 39740-82-4Leupeptin hydrochloride is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hydrochloride significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hydrochloride inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hydrochloride can be used in research on chronic inflammatory diseases and skin tumorigenesis.
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JW480 (Standard)
0 ImagesCat. No.: HY-107582RCAS No.: 1354359-53-7
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6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose
![6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose](https://file.medchemexpress.com/product_pic/hy-164125.gif "Click to View 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose Product Detail")
0 ImagesCat. No.: HY-164125CAS No.: 1404341-61-26-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose is an important signaling molecule that regulates carbon utilization and growth in plants. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose releases T6P through light activation, which can stimulate starch synthesis and promote plant growth by inhibiting SnRK1, a protein kinase involved in energy conservation and survival. 6-O-Bis[1-(2-nitrophenyl)-ethoxyphosphoryl]-D-trehalose can be used to study plant growth and metabolism.
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Benzamidine hydrochloride (Standard)
0 ImagesBenzamidine hydrochloride (Standard) is the analytical standard of Benzamidine (hydrochloride). This product is intended for research and analytical applications. Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results.
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β-Tryptase-IN-1
0 ImagesCat. No.: HY-185463CAS No.: 725228-46-6β-Tryptase-IN-1 is a selective β-tryptase inhibitor with a Ki of 10 nM. β-Tryptase-IN-1 binds to the inducible S4+ pocket unique to β-tryptase. β-Tryptase-IN-1 can be used for the researches of asthma and chronic obstructive pulmonary disease (COPD).
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IPR-803 (Standard)
0 ImagesCat. No.: HY-111192RCAS No.: 892243-35-5IPR-803 (Standard) is the analytical standard of IPR-803 (HY-111192). This product is intended for research and analytical applications. IPR-803 is a potent inhibitor of the uPAR·uPA protein-protein interaction (PPI). IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity.
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C1 Esterase Inhibitor (Human)
0 ImagesCat. No.: HY-P991629C1 Esterase Inhibitor (Human) is a C1 Esterase inhibitor derived from human plasma. C1 Esterase Inhibitor (Human), a glycoprotein, is a serum protease inhibitor (serpin) that binds covalently and inactivates C1r, C1s, and mannan-binding protein-associated proteases (MASPs). C1 Esterase Inhibitor (Human) has anti-inflammatory effects. C1 Esterase Inhibitor (Human) can be used to prevent angioedema attacks associated with hereditary angioedema.
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Dihydrofuran-3(2H)-one (Standard)
0 ImagesSynonyms: 3-Oxotetrahydrofuran (Standard)Dihydrofuran-3(2H)-one (Standard) is the analytical standard of Dihydrofuran-3(2H)-one. This product is intended for research and analytical applications. Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) is a cyclic ketone that can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin.
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PfSUB1-IN-2
0 ImagesCat. No.: HY-187525PfSUB1-IN-2 is an irreversible covalent peptidic diaryl phosphonate inhibitor of Plasmodium falciparum serine protease PfSUB1 with an IC50 of 167 nM and an EC50 of 22.2 μM against Plasmodium falciparum strain growth. PfSUB1-IN-2 can be used for the research of malaria.
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Berotralstat (Standard)
0 ImagesCat. No.: HY-109127RCAS No.: 1809010-50-1Synonyms: BCX7353 (Standard)Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
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Nacresertib
0 ImagesCat. No.: HY-159847CAS No.: 2629977-59-7Nacresertib is a Ser/Thr Protease inhibitor.
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Chymotrypsin-IN-1
0 ImagesCat. No.: HY-W426308CAS No.: 329-30-6Chymotrypsin-IN-1 (Compound TPCK) is a chymotrypsin inhibitor. Chymotrypsin-IN-1 can irreversibly inhibit chymotrypsin-like serine proteases.
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PAR-2-IN-2
0 ImagesCat. No.: HY-169817CAS No.: 313986-65-1PAR-2-IN-2 (compound P-596) is a protease-activated receptor 2 (PAR-2) inhibitor with an IC50 of 10.79 μM for SLIGKV and an IC50 of greater than 200 μM for Trypsin.
