Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
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Ser/Thr Protease Inhibitors
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Ser/Thr Protease Agonist
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Ser/Thr Protease Activators
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Ser/Thr Protease Modulator
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Ser/Thr Protease Degrader
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Ser/Thr Protease Control
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Ser/Thr Protease Substrates
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Ser/Thr Protease Ligand
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Ser/Thr Protease Related Products (379)
Related Products (379)
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Antibodies (11)
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SHR-2010
0 ImagesCat. No.: HY-P992463
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HG1 Toxin
0 ImagesCat. No.: HY-P10572HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (Ki=107 nM) and can be used in the study of autoimmune diseases.
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Z-APF-CMK
0 ImagesCat. No.: HY-P4368CAS No.: 217658-18-9
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(R)-pMeO-Bz-SF
0 ImagesCat. No.: HY-184117BCAS No.: 3098808-75-1(R)-pMeO-Bz-SF, the R isomer of pMeO-Bz-SF (HY-184117), is an α-chymotrypsin inhibitor with an IC50 of 101 nM. (R)-pMeO-Bz-SF covalently modifies Ser195, Ser190, and Tyr146 in or near α-chymotrypsin’s hydrophobic S1 binding pocket. (R)-pMeO-Bz-SF inhibits α-chymotrypsin in a stereoselective manner.
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Leupeptin hemisulfate (Standard)
0 ImagesLeupeptin hemisulfate (Standard) is the analytical standard of Leupeptin hemisulfate (HY-18234A ). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis.
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Patamostat mesylate
0 ImagesCat. No.: HY-114080ACAS No.: 114568-32-0Synonyms: E-3123 mesylatePatamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis.
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Nonadecanoic acid (Standard)
0 ImagesCat. No.: HY-W004261RCAS No.: 646-30-0Nonadecanoic acid (Standard) is the analytical standard of Nonadecanoic acid. This product is intended for research and analytical applications. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.
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AR antagonist 11
0 ImagesCat. No.: HY-173409CAS No.: 3005979-40-5AR antagonist 11 (Compound c2) is a selective AR antagonist with an IC50 of 0.019 μM. AR antagonist 11 is also effective against ARF877L/T878A mutant (IC50: 1.03 μM). AR antagonist 11 inhibits LNCaP cell proliferation and reduces PSA protein expression (IC50: 0.54 μM). AR antagonist 11 can be used for research of prostate cancer (PCa).
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DCLK1-IN-5
0 ImagesCat. No.: HY-161471CAS No.: 3028774-14-0
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CP 81282
0 ImagesCat. No.: HY-117641CAS No.: 121584-61-0CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension.
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BMS-354326
0 ImagesCat. No.: HY-120624CAS No.: 708258-16-6BMS-354326 is a tryptase inhibitor with an IC50 of 1.8 nM. BMS-354326 exhibits excellent selectivity against trypsin and most other related serine proteases. BMS-354326 can be used in the research of asthma and inflammatory diseases.
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UKI-1-d8 acetate
0 ImagesCat. No.: HY-100415S1Synonyms: WX-UK1-d8 acetate; UKI-1C-d8 acetateUKI-1-d8 acetate (WX-UK1-d8 acetate) is the deuterium labeled UKI-1 acetate. UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells.
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BMS-363131
0 ImagesCat. No.: HY-116033CAS No.: 384829-65-6BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model.
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VD4162
0 ImagesCat. No.: HY-161370CAS No.: 2574390-19-3
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TMP1
0 ImagesCat. No.: HY-175344TMP1 is an orally active bispecific inhibitor of M pro (IC50 = 312.5 nM)/TMPRSS2 (IC50 = 1.28 μM, KD = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab (HY-P9903). TMP1 can be used in coronavirus research.
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JNJ-27390467
0 ImagesCat. No.: HY-14515CAS No.: 1025795-12-3JNJ-27390467 is a potent, orally active, and selective tryptase inhibitor (human β-tryptase IC50 = 3.6 nM, Ki = 3.7 nM). JNJ-27390467 exhibits excellent selectivity over trypsin of ~5000-fold. JNJ-27390467 shows effects in animal models of airway inflammation. JNJ-27390467 can be used for allergic asthma research.
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BI-L-45 XX
0 ImagesCat. No.: HY-116230CAS No.: 111317-77-2
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APC-6860
0 ImagesCat. No.: HY-114015CAS No.: 154628-42-9APC-6860 is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 is applicable to research related to breast cancer and prostate cancer.
