Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
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Ser/Thr Protease Inhibitors
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Ser/Thr Protease Agonist
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Ser/Thr Protease Activators
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Ser/Thr Protease Modulator
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Ser/Thr Protease Degrader
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Ser/Thr Protease Control
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Ser/Thr Protease Substrates
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Ser/Thr Protease Ligand
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Ser/Thr Protease Related Products (379)
Related Products (379)
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Antibodies (11)
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Imidazole-15N2
0 ImagesSynonyms: Glyoxaline-15N2; 1,3-Diaza-2,4-cyclopentadiene-15N2Imidazole-15N2 (Glyoxaline-15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease.
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Tyrphostin 47
0 ImagesCat. No.: HY-101959ACAS No.: 118409-60-2Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation
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L 658758
0 ImagesCat. No.: HY-118459CAS No.: 116507-04-1L 658758 is a potent inhibitor of serine proteinase.
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2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol
0 ImagesCat. No.: HY-N18088CAS No.: 89079-38-92-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol is a bisphenol compound and a serine protease inhibitor. 2-O-(2,4,6-Trihydroxyphenyl)-6,6'-bieckol exhibits inhibitory activities against α2-macroglobulin, α2-plasmin inhibitor and plasmin, with corresponding IC50 values of 1.9 μg/mL, 0.7 μg/mL and 13 μg/mL.
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DPP-1-IN-1
0 ImagesCat. No.: HY-174380CAS No.: 2781135-27-9DPP-1-IN-1 (Compound 14) is an orally active inhibitor of Cathepsin C (also known as Dipeptidyl peptidase I) with an IC50 of 5.31 nM. DPP-1-IN-1 can inhibit the activity of Cathepsin C downstream Neutrophil elastase in neutrophils. DPP-1-IN-1 can be used in the research of inflammatory diseases.
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AAF-CMK
0 ImagesCat. No.: HY-129407ACAS No.: 102129-66-8AAF-CMK is a TPPII (tripeptidylpeptidase II) inhibitor, shows anti-tumor activity and induces apoptosis. AAF-CMK can be used in leukemia research.
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MASP-2-IN-1
0 ImagesCat. No.: HY-172090CAS No.: 3103336-29-1
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TNIK-IN-2
0 ImagesTNIK-IN-2 is a Traf2- and Nck-interacting protein kinase (TNIK) inhibitor, with an IC50 of 1.3337 μM. TNIK-IN-2 can be used for the study of colorectal cancer (CRC).
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(S)-pMeO-Bz-SF
0 ImagesCat. No.: HY-184117ACAS No.: 3117686-58-2(S)-pMeO-Bz-SF, the S isomer of pMeO-Bz-SF (HY-184117A), is a potent covalent serine hydrolase inhibitor with an α-chymotrypsin IC50 of 2.965 μM. (S)-pMeO-Bz-SF covalently modifies α-chymotrypsin residues Ser195, Tyr146, and Ser190. (S)-pMeO-Bz-SF exhibits stereoselective inhibitory activity against α-chymotrypsin.
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(E)-Upamostat-d5
0 ImagesCat. No.: HY-16511ASSynonyms: (E)-WX-671-d5(E)-Upamostat-d5 ((E)-WX-671-d5) is the deuterium labeled (E)-Upamostat (HY-16511A). (E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor.
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WX-293
0 ImagesCat. No.: HY-182450CAS No.: 282718-42-7WX-293 is a highly selective urokinase-type plasminogen activator (uPA) inhibitor with a Ki value of 2.4 μM. WX-293 abolishes hypoxia-induced keratinocyte migration and in vitro wound closure. WX-293 can be used in research on hypoxia-mediated skin wounds and solid malignant tumors.
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Kallikrein-IN-2
0 ImagesCat. No.: HY-143867CAS No.: 2702983-84-2Kallikrein-IN-2 (compound 1) is a Kallikrein inhibitor.
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FXIIa-IN-6
0 ImagesCat. No.: HY-184008CAS No.: 3107571-66-1FXIIa-IN-6 is a potent, selective, and irreversible covalent inhibitor of Factor XIIa (FXIIa) with an IC50 of 2 nM. FXIIa-IN-6 exhibits ≥2,500-fold selectivity over related serine proteases. FXIIa-IN-6 exhibits favorable anticoagulant and anti-inflammatory activities and can be used in sepsis research.
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Anti-HGFA Antibody
0 ImagesCat. No.: HY-P990431Anti-HGFA Antibody is a humanized antibody expressed in CHO cells, targeting HGFA. The Anti-HGFA Antibody contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-HGFA Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Oscillamide Y
0 ImagesCat. No.: HY-P11335CAS No.: 168482-80-2Oscillamide Y (Compound 1), a ureido-containing cyclic peptide, is a Chymotrypsin inhibitor. Oscillamide Y can be isolated from freshwater toxic cyanobacterium Oscillatoria agardhii. Oscillamide Y has potent toxicity against fish, daphnid magna and algae with a stimulatory effect for Raphidocelis subcapitata (EC50: 4.62 mg/L). Oscillamide Y induces high luminescence inhibition in Aliivibrio fischeri. Oscillamide Y can be used for ecological development research.
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NCO-650 free base
0 ImagesCat. No.: HY-182414CAS No.: 81907-78-0NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma.
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Upamostat hydrogen sulfate
0 ImagesCat. No.: HY-16512CAS No.: 798560-68-6Synonyms: WX-671 hydrogen sulfateUpamostat (WX-671) hydrogen sulfate, a prodrug of WX-UK1 (HY-100415), is an orally active serine protease inhibitor. Upamostat hydrogen sulfate inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat hydrogen sulfate can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer.
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(E)-Upamostat
0 ImagesCat. No.: HY-16511ACAS No.: 1191101-18-4Synonyms: (E)-WX-671(E)-Upamostat ((E)-WX-671) is an E-isomer of Upamostat (HY-16511). Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor.
