Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
All Product Categories
-
Ser/Thr Protease Inhibitors
(239)
View all products
-
Ser/Thr Protease Agonist
(1)
View all products
-
Ser/Thr Protease Activators
(7)
View all products
-
Ser/Thr Protease Modulator
(1)
View all products
-
Ser/Thr Protease Degrader
(1)
View all products
-
Ser/Thr Protease Control
(1)
View all products
-
Ser/Thr Protease Substrates
(21)
View all products
-
Ser/Thr Protease Ligand
(1)
View all products
-
Ser/Thr Protease Related Products (379)
Related Products (379)
-
Antibodies (11)
-
Bz-D-Arg-pNA hydrochloride
0 ImagesCat. No.: HY-147167CAS No.: 21653-41-8Bz-D-Arg-pNA hydrochloride is a competitive trypsin inhibitor.
-
Retrocyclin-101
0 ImagesCat. No.: HY-P5642CAS No.: 536757-16-1Synonyms: RC-101Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression.
-
MOL-6131
0 ImagesCat. No.: HY-15132CAS No.: 583868-50-2MOL-6131 is a highly selective, reversible tryptase inhibitor, with a Ki of 45 nM. MOL-6131 significantly reduces the following features of allergic airway inflammation: eosinophil infiltration in lung tissue, goblet cell hyperplasia and mucus occlusion of airways.
-
ZK824859
0 ImagesCat. No.: HY-114330CAS No.: 2271122-53-1ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
-
Factor VII-IN-1
0 ImagesCat. No.: HY-147393CAS No.: 244206-28-8Factor VII-IN-1 (example 43) is a potent inhibitor of factor VII (FVII), with an IC50 of 1.1 μM. Factor VII-IN-1 shows anticoagulant properties.
-
NK3201
0 ImagesCat. No.: HY-12514CAS No.: 204460-24-2NK3201 is an orally active chymase inhibitor (IC50: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein.
-
Leupeptin Ac-LL
0 ImagesCat. No.: HY-18234BCAS No.: 24365-47-7Leupeptin Ac-LL is a broad-spectrum protease inhibitor. By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin Ac-LL significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin Ac-LL inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin Ac-LL can be used in research on chronic inflammatory diseases and skin tumorigenesis.
-
DCLK1-IN-2
0 ImagesCat. No.: HY-155303CAS No.: 2978517-43-8DCLK1-IN-2 (compound I-5) is a potent DCLK1 inhibitor with an IC50 of 171.3 nM. DCLK1-IN-2 shows remarkable antiproliferative effects on SW1990 cell lines (IC50 of 0.6 μM) and in vivo antitumor potency.
-
UAMC-00050
0 ImagesCat. No.: HY-151611CAS No.: 2842774-51-8UAMC-00050 is a potent trypsin-like serine protease inhibitor. UAMC-00050 can be used in research of dry eye syndrome and ocular inflammation.
-
APC 366 hydrochloride
0 ImagesCat. No.: HY-105999ACAS No.: 178925-65-0
-
APC-6860 (hydrochloride)
0 ImagesCat. No.: HY-W794573CAS No.: 149732-36-5APC-6860 hydrochloride is a competitive, selective arylamidine Serine protease inhibitor, with a Ki of 0.44 μM for trypsin, 0.10 μM for h-uPA, and 0.082 μM for mouse uPA. APC-6860 hydrochloride inhibits urokinase-activated plasminogen-mediated degradation of Fibronectin in cancer cells. APC-6860 hydrochloride is applicable to research related to breast cancer and prostate cancer.
-
Butabindide
0 ImagesCat. No.: HY-150070CAS No.: 175553-48-7Synonyms: UCL-1397Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation.
-
TMPRSS13-IN-1
0 ImagesCat. No.: HY-169250CAS No.: 3124504-57-7TMPRSS13-IN-1 (N-0430) is a potent TMPRSS13 inhibitor with a Ki of 25 nM.
-
VU6083859
0 ImagesCat. No.: HY-181280Purity: 99.75%VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC50 of 158 nM. VU6083859 selectively inhibits TAOK1, exhibits only weak or no activity against TAOK2 and TAOK3, and shows high selectivity for a variety of other kinases. VU6083859 is applicable to research related to neurodevelopmental disorders and tauopathies.
-
RLYB331
0 ImagesCat. No.: HY-P992451Synonyms: KY1066RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6). RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia.
-
Urinary Trypsin Inhibitor Fragment
0 ImagesCat. No.: HY-P34013CAS No.: 164859-77-2Urinary Trypsin Inhibitor Fragment is a fragment derived from urinary trypsin inhibitor by proteolysis. Urinary Trypsin Inhibitor Fragment can inhibit tumor cell invasion by limited proteolysis.
-
Trypsin-IN-2
0 ImagesCat. No.: HY-153047CAS No.: 1984788-85-3Trypsin-IN-2 (Compound 12) is an efficient and highly selective inhibitor of human trypsin, with an IC₅₀ of 8 nM. Trypsin-IN-2 can be used for research on pancreatic cancer.
-
DPC423 free base
0 ImagesCat. No.: HY-11090CAS No.: 209957-47-1DPC423 free base is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis.
-
CDD-1115
0 ImagesCat. No.: HY-171248CAS No.: 3034215-86-3CDD-1115 is a BMPR2 serine/threonine kinase inhibitor with an IC50 of 1.8 nM against human BMPR2 kinase. CDD-1115 selectively inhibits the catalytic activity of BMPR2, and shows weak inhibitory effects on ALK1 and ALK2.
