Ser/Thr Protease
Serine proteases; Serine endopeptidases; Threonine proteases
Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.
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Ser/Thr Protease Inhibitors
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Ser/Thr Protease Agonist
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Ser/Thr Protease Activators
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Ser/Thr Protease Modulator
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Ser/Thr Protease Degrader
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Ser/Thr Protease Control
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Ser/Thr Protease Substrates
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Ser/Thr Protease Ligand
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Ser/Thr Protease Related Products (379)
Related Products (379)
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Antibodies (11)
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Thrombin inhibitor 7
0 ImagesCat. No.: HY-152150CAS No.: 2866508-00-9
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XMD-17-51
0 ImagesCat. No.: HY-117291CAS No.: 1628614-50-5XMD-17-51 is a pyrimido-diazepinone compound that is able to modulate protein kinases.
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DRAK2-IN-2
0 ImagesCat. No.: HY-184326CAS No.: 3080324-43-9DRAK2-IN-2 is a selective DRAK2 inhibitor with an IC50 value of 198.5 nM. DRAK2-IN-2 inhibits DRAK2-mediated phosphorylation of ULK1 at the Ser56 site. DRAK2-IN-2 enhances insulin secretion, increases mitochondrial membrane potential, alleviates Palmitic acid (HY-N0830)-induced mitochondrial membrane potential damage and Apoptosis, and improves glucose tolerance in vivo. DRAK2-IN-2 can be used for the research of type 2 diabetes.
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GGACK hydrochloride
0 ImagesCat. No.: HY-137495AGGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor.
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pMeO-Bz-SF
0 ImagesCat. No.: HY-184117CAS No.: 3061644-67-2pMeO-Bz-SF is a covalent, stereoselective α-chymotrypsin inhibitor with an IC50 value of 133 nM. The (R)-enantiomer of pMeO-Bz-SF ((R)-pMeO-Bz-SF (HY-184117B)) inhibits α-chymotrypsin with an IC50 of 101 nM. The (S)-enantiomer of pMeO-Bz-SF ((S)-pMeO-Bz-SF (HY-184117A)) shows low activity against α-chymotrypsin, with an IC50 of 2965 nM.
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PAI-1
0 ImagesPAI-1 is a serine protease inhibitor (SERPIN). PAI-1 binds to and irreversibly inhibits uPA, tPA and furin; it also interacts with vitronectin, α1-acid glycoprotein, CRT, TLR4, proteasome α-3 subunit, uPAR, LRP1, Integrin αvβ3 and thrombin. PAI-1 regulates fibrinolysis, extracellular matrix turnover, cell migration, angiogenesis, inflammatory response and tissue remodeling; it mediates epithelial-mesenchymal transition (EMT)/endothelial-mesenchymal transition (EndMT), apoptosis and thrombus stabilization. PAI-1 can be used in research related to sepsis, acute lung injury, cardiovascular diseases, tissue fibrosis, diabetic nephropathy, obstructive nephropathy and non-insulin-dependent diabetes mellitus.
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TNIK-IN-4
0 ImagesCat. No.: HY-143436CAS No.: 2754266-04-9TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116.
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PTAD-ergosta-3-one
0 ImagesCat. No.: HY-187095PTAD-ergosta-3-one is a snake venom enzyme inhibitor. PTAD-ergosta-3-one inhibits the procoagulant activity of citrated plasma mediated by serine protease (SVSP) from Bothrops asper venom. PTAD-ergosta-3-one inhibits the esterase activity of PLA2 from Bothrops asper venom. PTAD-ergosta-3-one can be used in the research of snakebite envenoming.
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Debrisoquin hydrobromide
0 ImagesSynonyms: Debrisoquine hydrobromide; Isocaramidine hydrobromide; Ro 5-3307/1 hydrobromide
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Alpha 1 Antichymotrypsin, Human Plasma
0 ImagesCat. No.: HY-P2978CAS No.: 141176-92-3Alpha 1 Antichymotrypsin, Human Plasma is a serine protease inhibitor. Alpha 1 Antichymotrypsin, Human Plasma appears in the amyloid lesions of Alzheimer's disease. Alpha 1 Antichymotrypsin, Human Plasma can be used in Alzheimer's disease research.
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DPC423
0 ImagesCat. No.: HY-11090ACAS No.: 292135-59-2DPC423 is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis.
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RWJ-58643
0 ImagesCat. No.: HY-19472CAS No.: 287183-00-0RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells.
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HMB-Val-Ser-Leu-VE
0 ImagesCat. No.: HY-137281CAS No.: 862891-04-1HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC50 of 0.033 μM.
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Patamostat hydrochloride
0 ImagesCat. No.: HY-114080BCAS No.: 3031765-17-7Synonyms: E-3123 hydrochloridePatamostat hydrochloride is a potent protease inhibitor. Patamostat hydrochloride potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat hydrochloride may possess suppressing effects on pathogenesis and development of acute pancreatitis.
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Nostosin G
0 ImagesCat. No.: HY-N3997CAS No.: 3033950-58-9Nostosin G is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal. Nostosin G has potent trypsin inhibitory property with an IC50 value of 0.1 μM.
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Kallikrein-IN-1
0 ImagesCat. No.: HY-143866CAS No.: 1933514-53-4Kallikrein-IN-1 (Formula A) is a Kallikrein inhibitor.
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Dansyl-Glu-Gly-Arg-Chloromethylketone
0 ImagesCat. No.: HY-P4243CAS No.: 69024-84-6Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases. Dansyl-Glu-Gly-Arg-Chloromethylketone inhibits activated porcine factor IX.
