181586-07-2
181586-07-2
Chemical Structure
ONO-3403
- CAS No.: 181586-07-2
- Formula:C26H31N3O8S
- Molecular Weight:545.60
IUPAC Name: 4-carbamimidoylphenyl (E)-4-(3-(allyl(2-ethoxy-2-oxoethyl)amino)-2-methyl-3-oxoprop-1-en-1-yl)benzoate methanesulfonate
InChIKey: PKBZGVVSSNNHGY-INTLEYBYSA-N
SMILES: O=C(C1=CC=C(C=C1)/C=C(C(N(CC=C)CC(OCC)=O)=O)\C)OC2=CC=C(C=C2)C(N)=N.CS(=O)(O)=O
Biological Activity: ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors[1][2][3][4].
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ONO-3403 | ONO-3403 is an orally active serine protease inhibitor. ONO-3403 inhibits the production of TNF-α and nitric oxide induced by LPS. ONO-3403 inhibits the cell growth and induces the apoptosis, and has an antitumor effect on malignant tumors. | |||||||||||||||||||||
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References
- [1]. Tumurkhuu G, et al. ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Innate Immun. 2011;17(1):97-105. [Content Brief]
- [2]. Hiwasa T, et al. Potent growth-suppressive activity of a serine protease inhibitor, ONO-3403, toward malignant human neuroblastoma cell lines. Cancer Lett. 1998;126(2):221-225. [Content Brief]
- [3]. Ohkoshi M, et al. Growth inhibition of mouse autochthonous skin cancer by oral administration of new serine protease inhibitor ONO-3403. Anticancer Res. 2002;22(2A):821-823. [Content Brief]
