118409-60-2
118409-60-2
Chemical Structure
Tyrphostin 47
- CAS No.: 118409-60-2
- Formula:C10H8N2O2S
- Molecular Weight:220.25
IUPAC Name: (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide
InChIKey: ZGHQGWOETPXKLY-XVNBXDOJSA-N
SMILES: S=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1
Biological Activity: Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation[1][2]
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Tyrphostin 47 | Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation | |||||||||||||||||||||
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References
- [1]. Erfinanda L, et al. Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. Sci Transl Med. 2022 Dec 7;14(674):eabg8577. [Content Brief]
- [2]. Gottsauner-Wolf M, et al. Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model. Am Heart J. 1997 Mar;133(3):329-34. [Content Brief]
