2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. SHR-2010

SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy.

For research use only. We do not sell to patients.

SHR-2010

SHR-2010 Chemical Structure

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SHR-2010 Related Antibodies

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Description

SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy[1].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

SHR-2010 (0.390625-50 nM; 60 s) binds with high affinity to human and rhesus monkey MASP-2 (KD of 3.49×10-10 M and 1.38×10-10 M, respectively) and weak affinity to mouse MASP-2 (KD = 3.81×10-8 M)[1].
SHR-2010 (30 min with serum at 4°C) potently inhibits the lectin pathway in human serum (IC50 = 6.44 nM) and rhesus monkey serum (IC50 = 144.2 nM) but has no effect on rodent serum lectin pathway activity[1].
SHR-2010 (3.2-2000 nM; 30 min) selectively inhibits only the lectin pathway, with no effect on the classical or alternative complement pathways in human serum at concentrations up to 2000 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SHR-2010 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Cmax AUC0-t AUC0-∞ Vd CL MRT Bioavailability
Rhesus monkey[1] 0.5 mg/kg i.v. 226.3 h 10.6 μg/mL 1230 μg·h/mL 1463 μg·h/mL 135.9 mL/kg 0.51 mL/h/kg 182.4 h /
Rhesus monkey[1] 1.5 mg/kg i.v. 140.4 h 43.6 μg/mL 5068.5 μg·h/mL 5188.9 μg·h/mL 64.1 mL/kg 0.3 mL/h/kg 191.9 h /
Rhesus monkey[1] 5 mg/kg i.v. 175.9 h 148.4 μg/mL 28075.3 μg·h/mL 30433 μg·h/mL 39.4 mL/kg 0.18 mL/h/kg 257.4 h /
Rhesus monkey[1] 5 mg/kg s.c. 142.8 h 74.6 μg/mL 29347.2 μg·h/mL 31336.5 μg·h/mL 31.3 mL/kg 0.18 mL/h/kg 275.8 h 104.5 %
In Vivo

SHR-2010 (0.5-5 mg/kg; i.v. or s.c. (5 mg/kg); single dose) inhibits the lectin pathway in healthy rhesus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rhesus monkeys[1]
Dosage: 0.5; 1.5; 5 mg/kg
Administration: i.v. or s.c. (5 mg/kg); single dose
Result: Achieved maximum lectin pathway inhibition at 1 hour post single 5 mg/kg i.v. administration, with inhibitory effects persisting for 408 hours.
Maintained serum concentrations above 30,000 ng/mL and lectin pathway inhibition above 65% for 408 hours post single 5 mg/kg i.v. administration.
Exhibited dose-dependent inhibition of the lectin pathway in rhesus monkey serum.
Produced 65.8-80.1% lectin pathway inhibition persisting for 408 hours after a single 5 mg/kg intravenous dose.
Gene ID

10747  [NCBI]

Accession
Target

MASP2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SHR-2010 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SHR-2010SHR2010SHR 2010Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesMannan-binding lectin-associated serine protease-2IgA nephropathylectin pathwayCCP1 domainhuman serumclassical complement pathwaynon-human primatesalternative complement pathwayrhesus monkey serumMASP-2Inhibitorinhibitorinhibit

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