71079-09-9
71079-09-9
Chemical Structure
FOY 251
- CAS No.: 71079-09-9
- Formula:C17H19N3O7S
- Molecular Weight:409.41
IUPAC Name: 2-(4-((4-guanidinobenzoyl)oxy)phenyl)acetic acid compound with methanesulfonic acid (1:1)
InChIKey: JXMOPIDYHUYOED-UHFFFAOYSA-N
SMILES: O=C(O)CC1=CC=C(OC(C2=CC=C(NC(N)=N)C=C2)=O)C=C1.CS(=O)(O)=O
Biological Activity: FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor[1][2]. FOY 251 inhibits SARS-CoV-2 infection in cells assay[1][3].
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FOY 251 | 99.31% | FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay. | ||||||||||||||||||||
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FOY 251 (Standard) | ≥98% | FOY 251 (Standard) is the analytical standard of FOY 251. This product is intended for research and analytical applications. FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay. | ||||||||||||||||||||
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FOY 251-d4 | FOY 251-d4 is the deuterium labeled FOY 251 (HY-19727A). FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-19727FOY 251 free base -
Similarity Score 0.80
HY-13512Camostat mesylate -
Similarity Score 0.76
HY-165529Camostat -
Similarity Score 0.76
HY-19101ONO-3307 -
Similarity Score 0.74
HY-147931Human enteropeptidase-IN-2 -
Similarity Score 0.73
HY-167924Ono 3307 free base -
Similarity Score 0.71
HY-1378144-Nitrophenyl 4-guanidinobenzoate hydrochloride -
Similarity Score 0.66
HY-114080APatamostat mesylate -
Similarity Score 0.66
HY-B0190ANafamostat mesylate -
Explore the MedChemAI to find more analogs
References
- [1]. K Beckh, et al. Elimination of the Low-Molecular Weight Proteinase Inhibitor Camostate (FOY 305) and Its Degradation Products by the Rat Liver. Res Exp Med (Berl). 1987;187(6):401-6. [Content Brief]
- [2]. Ai Maekawa, et al. Camostat Mesilate Inhibits Prostasin Activity and Reduces Blood Pressure and Renal Injury in Salt-Sensitive Hypertension. J Hypertens . 2009 Jan;27(1):181-9. [Content Brief]
- [3]. Markus Hoffmann, et al. Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. bioRxiv. 2020 Aug 5;2020.08.05.237651. [Content Brief]
