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United States

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Referencia número: HY-187525

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PfSUB1-IN-2

PfSUB1-IN-2 is an irreversible covalent peptidic diaryl phosphonate inhibitor of Plasmodium falciparum serine protease PfSUB1 with an IC₅₀ of 167 nM and an EC₅₀ of 22.2 μM against Plasmodium falciparum strain growth. PfSUB1-IN-2 can be used for the research of malaria.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₆H₄₃F₂N₄O₇P
Peso molecular:712.72

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

PfSUB1-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Parasite :

In Vitro

Parasitic Infection

PfSUB1-IN-2 (compound 3b) (167 nM-20 μM; 30 min) irreversibly inhibits purified Plasmodium falciparum PfSUB1 with an IC₅₀ of 167 nM after 30 min of pre-incubation, and achieves full inhibition at 20 μM^[1].
PfSUB1-IN-2 (72 h) inhibits the growth of Plasmodium falciparum 3D7 strain in red blood cells with an EC₅₀ of 22.2 μM in 72-hour dose-response assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 712.72
Fòrmula C₃₆H₄₃F₂N₄O₇P
SMILES

O=C(N[C@@H]([C@H](CC)C)C(NCC(NC(C)P(OC1=CC=C(F)C=C1)(OC2=CC=C(F)C=C2)=O)=O)=O)[C@@H](NC(C3=CC=CC=C3)=O)C4CCCC4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Armands Kazia, et al. Peptidic Phosphonates as Irreversible Covalent Inhibitors of Plasmodium falciparum Serine Protease PfSUB1. ACS Med. Chem. Lett. 13 August 2026; 17 (8): 1873–1877.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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