Serotonin Transporter
5-HTT; SERT; SLC6A4
Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.
Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.
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Serotonin Transporter Inhibitors
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Serotonin Transporter Agonists
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Serotonin Transporter Antagonists
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Serotonin Transporter Activators
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Serotonin Transporter Modulators
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Serotonin Transporter Controls
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Serotonin Transporter Substrates
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Serotonin Transporter Ligands
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Serotonin Transporter Related Products (317)
Related Products (317)
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Antibodies (3)
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SERT-IN-5
0 ImagesCat. No.: HY-183269SERT-IN-5 is a potent, selective, and CNS-penetrant serotonin transporter (SERT) inhibitor with a Ki of 0.3 nM. SERT-IN-5 blocks serotonin reuptake to increase synaptic serotonin levels. SERT-IN-5 exhibits anti-anxiety effects in mice. SERT-IN-5 can be used for the research of anxiety, depression.
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Milnacipran-d5 hydrochloride
0 ImagesCat. No.: HY-B0168ASCAS No.: 2750534-79-1Milnacipran-d5 hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia).
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Venlafaxine-d9
0 ImagesCat. No.: HY-B0196S4CAS No.: 940297-30-3Synonyms: Wy 45030-d9Venlafaxine-d9 (Wy 45030-d9) is a deuterium labeled Venlafaxine (HY-B0196). Venlafaxine (Wy 45030) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant.
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Paroxetine-d4 hydrochloride
0 ImagesSynonyms: BRL29060-d4 hydrochloride; BRL29060A-d4Paroxetine-d4 (hydrochloride) is deuterium labeled Paroxetine (hydrochloride). Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an and has GRK2 inhibitory ability with IC50 of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder.
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(R)-Citalopram-d4 oxalate
0 ImagesCat. No.: HY-110289S1CAS No.: 2747918-87-0(R)-Citalopram-d4 (oxalate) is deuterium labeled (R)-Citalopram Oxalate. (R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression.
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UCD0168
0 ImagesCat. No.: HY-175720UCD0168 is a Serotonin transporter (SERT) inhibitor that acts as a full serotonin releasing agent (SRA). UCD0168 can be used for depression, addiction and post-traumatic stress disorder (PTSD) research.
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2-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride
0 ImagesCat. No.: HY-W703376CAS No.: 63199-74-62-(tert-Butylamino)-1-phenylpropan-1-one hydrochloride (Compound Imp.1) is a non-selective monoamine transporter (DAT/NET/SERT) agonist. tert-Butylcathinone hydrochloride is promising for research of depressive disorders.
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Desvenlafaxine succinate
0 ImagesSynonyms: O-Desmethylvenlafaxine succinate; Wy-45233 succinateDesvenlafaxine succinate, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine succinate (DVS) shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter.
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Cendifensine
0 ImagesCat. No.: HY-172421CAS No.: 1034048-49-1Cendifensine is the inhibitor for monoamine reuptake that inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).
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Metrenperone
0 ImagesCat. No.: HY-121311CAS No.: 81043-56-3Metrenperone is an inhibitor for 5-HT2 receptor. Metrenperone exhibits α1 and α2 antagonist activity as well as anti-H1 and anti-dopaminergic efficacy. Metrenperone can lower the blood pressure, enhances bradycardia in peripheral ischemia, inhibits serotonin-induced platelet aggregation, and antagonizes serotonin-mediated vasoconstriction. Metrenperone promotes the repair of acutely damaged collagen tissue.
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Tat-SERT-15C
0 ImagesCat. No.: HY-P11222CAS No.: 2614435-43-5Tat-SERT-15C is a peptide. Tat-SERT-15C decreases the SERT-nNOS complex and increases SERT. Tat-SERT-15C reverses chronic unpredictable mild stress-caused depression behaviors.
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Dimephosphon
0 ImagesCat. No.: HY-176248CAS No.: 14394-26-4Dimephosphon is an anti-inflammatory agent with antihistamine and antiserotonin activities. Dimephosphon helps maintain the conduction function of the spinal cord and reduces the excitability of spinal motor neurons in the area surrounding the lesion. Dimephosphon directly activates lymphatic vessel movement and improves lymphatic circulation. Dimephosphon can be used for the study of inflammatory edema, acute spinal cord injury and lymphatic circulation disorders.
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Fluoxetine-d6 oxalate
0 ImagesCat. No.: HY-B0102SACAS No.: 2319722-08-0Synonyms: LY-110140-d6 oxalateFluoxetine-d6 oxalate (LY-110140-d6 oxalate) is the deuterium labeled Fluoxetine oxalate. Fluoxetine oxalate is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
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Citalopram-d3 hydrobromide
0 ImagesCat. No.: HY-B1287SSynonyms: (±)-Citalopram-d3 hydrobromide; Lu 10-171-d3Citalopram-d3 ((±)-Citalopram-d3) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC50 of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC50 of 14 nM. Antidepressant effect.
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NMDAR antagonist 5
0 ImagesCat. No.: HY-173398CAS No.: 3038464-68-2NMDAR antagonist 5 (Compound A17) is a multi-target antagonist against NMDAR and monoamine transporters (SERT、DAT and NET). NMDAR antagonist 5 shows good NMDAR antagonistic potency (IC50 = 0.3 μM) and monoamine transporter activities (SERT IC50 = 1.1 μM、DAT IC50 = 0.7 μM、NET IC50 = 2.7 μM). NMDAR antagonist 5 is highly safe and has low toxicity (hepatotoxicity and nephrotoxicity (IC50 > 100 μM); cardiotoxicity (IC50 = 24.5 μM)). NMDAR antagonist 5 has antidepressant effects and can be used in the study of depression.
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Histamine H3 antagonist-1
0 ImagesCat. No.: HY-160668CAS No.: 1000392-25-5Histamine H3 antagonist-1 (Compound 10o) is a histamine H3 antagonist and a serotonin reuptake inhibitor, which can be used in depression research.
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Paroxetine-d6-1
0 ImagesCat. No.: HY-122272S2CAS No.: 1435728-63-4Synonyms: BRL29060-d6-1Paroxetine-d6-1 (BRL29060-d6-1) is the deuterated-labeled Paroxetine (HY-122272). Paroxetine (BRL29060) is an orally active and selective serotonin reuptake inhibitor (SSRI) and apoptosis inducer with blood-brain barrier permeability. Paroxetine inhibits nitric oxide synthase and CYP2D6, induces desensitization of 5-HT1A/1B/1D autoreceptors, downregulates 5-HT2 receptors, and promotes the production of inflammatory cytokines. Paroxetine is a weak norepinephrine (NE) uptake inhibitor and possesses antitumor activity. Paroxetine is widely used in research concerning depression, obsessive-compulsive disorder, panic disorder, social phobia, generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, hot flashes, and related conditions.
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Gentisein (Standard)
0 ImagesCat. No.: HY-118166RCAS No.: 529-49-7Synonyms: NSC 329491 (Standard); 1,3,7-Trihydroxyxanthone (Standard)Gentisein (Standard) (NSC 329491 (Standard); 1,3,7-Trihydroxyxanthone (Standard)) is the analytical standard of Gentisein (HY-118166). This product is intended for research and analytical applications. Gentisein (NSC 329491) is a metabolite of Mangiferin (HY-N0290) that inhibits the serotonin transporter (5-HT uptake system). Gentisein suppresses serotonin uptake and can be used in studies related to depression.
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Fluvoxamine (Standard)
0 ImagesSynonyms: DU-23000 (Standard)Fluvoxamine (Standard) is the analytical standard of Fluvoxamine. This product is intended for research and analytical applications. Fluvoxamine (DU-23000) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor.
