Sirtuin
Sirtuins are a conserved family of NAD+-dependent deacylases and class III histone deacetylases that couple cellular energy status to transcriptional and metabolic regulation, thereby influencing stress adaptation, genome maintenance, and cellular homeostasis[1][2]. Mechanistically, sirtuins respond to fluctuations in NAD+ availability and regulate pathways associated with oxidative stress resistance, mitochondrial function, DNA repair, and metabolic efficiency through deacylation of histone and non-histone protein targets[2][3][4]. These activities place sirtuins at the intersection of nutrient sensing and cellular responses to environmental and physiological perturbations, including fasting, caloric restriction, DNA damage, and redox imbalance[2][4]. In disease-relevant contexts and experimental models, altered sirtuin activity has been linked to aging-related functional decline, metabolic disorders, inflammation, and impaired mitochondrial homeostasis, making the family an important framework for mechanistic studies of age-associated pathophysiology[2][5]. Compared with related isoforms, mammalian SIRT1-SIRT7 display distinct subcellular localization and biological functions, with SIRT1, SIRT6, and SIRT7 enriched mainly in the nucleus, SIRT2 primarily localized in the cytoplasm, and SIRT3, SIRT4, and SIRT5 concentrated in mitochondria, supporting isoform-specific regulation of cellular processes[1][3]. For experimental applications, sirtuin-modulating compounds, including sirtuin-activating compounds and inhibitors such as nicotinamide, are widely used to investigate NAD+-dependent signaling networks and the contribution of individual sirtuin isoforms to metabolism, aging, and disease mechanisms[5][6].
References:
- [1]. Zhao L, et al. Sirtuins and their Biological Relevance in Aging and Age-Related Diseases. Aging Dis. 2020 Jul 23;11(4):927-945. [Content Brief]
- [2]. Imai S, et al. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014 Aug;24(8):464-71. [Content Brief]
- [3]. Shahgaldi S, et al. A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism. Life Sci. 2021;282:119803.
- [4]. Imai S, et al. It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech Dis. 2016;2:16017.
- [5]. Bonkowski MS, et al. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690. [Content Brief]
- [6]. Wikipedia.
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Sirtuin Related Products (150)
Related Products (150)
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Decapeptide-12
0 ImagesDecapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
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Arjunolic acid
0 ImagesArjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction.
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Sirtuin modulator 6
0 ImagesSirtuin modulator 6 (compound 262) increases the lifespan of a cell. Sirtuin modulator 6 can be used for study of diabetes, obesity, neurodegenerative diseases, cardiovascular disease, and so an extracted from patent WO2009064913A1.
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SIRT5 inhibitor 7
0 ImagesSIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury.
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Sirtuin modulator 8
0 ImagesCat. No.: HY-173463CAS No.: 925437-38-3Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases.
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Agalloside
0 ImagesAgalloside is a neural stem cell differentiation activator that binds to Hes1, and it is found in Aquilaria agallocha. Agalloside promotes the differentiation of neural stem cells and increases the number of neurons. Agalloside can be used in studies related to neural stem cell differentiation.
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Pegloxenatide
0 ImagesCat. No.: HY-P3491CAS No.: 2420483-82-3Synonyms: Polyethylene glycol loxenatide; PEX 168Pegloxenatide (Polyethylene glycol loxenatide) is a long-acting glucagon-like peptide-1 receptor (GLP-1RA) agonist. Pegloxenatide has various activities such as lowering blood glucose, lowering blood lipids, improving body weight, anti-inflammation, promoting wound healing, protecting the liver, and protecting the heart. Pegloxenatide can be used in the research of type 2 diabetes and its multiple complications.
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SIRT1 activator 3
0 ImagesSIRT1 activator 3 is a potent activator of Sirt1 and suppresses TNF-α in a dose-dependent manner. SIRT1 activator 3 has the potential for anti-obesity or anti-diabetic researches.
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DDL-218
0 ImagesDDL-218 is an orally active and potent SirT1 inhibitor. DDL-218 enhances SirT1 in ApoE4-expressing neurons and a murine AD model. DDL-218 can be used in the study of Alzheimer's disease.
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AdipoR agonist 1
0 ImagesCat. No.: HY-130479CAS No.: 949745-75-9AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor (AdipoR), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research.
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Withanoside IV
0 ImagesWithanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19).
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Selisistat (Standard)
0 ImagesSynonyms: EX-527 (Standard)Selisistat (Standard) is the analytical standard of Selisistat. This product is intended for research and analytical applications. Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease.
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Sirt1/2-IN-2
0 ImagesCat. No.: HY-155727CAS No.: 670267-73-9Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines.
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Fisetin-d5
0 ImagesFisetin-d5 is a deuterated labeled Fisetin. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
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Nicotinamide-15N,13C3
0 ImagesCat. No.: HY-B0150S1CAS No.: 2117346-85-5Synonyms: Niacinamide-15N,13C3; Nicotinic acid amide-15N,13C3Nicotinamide-15N,13C3 is the 13C-labeled and 15N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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Nicotinamide-13C,15N
0 ImagesCat. No.: HY-B0150S4Purity: 98.71%Synonyms: Niacinamide-13C,15N; Nicotinic acid amide-13C,15NNicotinamide-13C,15N (Niacinamide-13C,15N) is the 13C- and 15N-labeled Nicotinamide (HY-B0150). Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity.
