Decapeptide-12
Based on 1 Customer Validation
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation .
For research use only. We do not sell to patients.
- Purity: 99.68%
- CAS No.: 137665-91-9
- Formula: KS3WY3
- Molecular Weight:1395.52
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Decapeptide-12 (P4, 0.01-10 mΜ) dose-dependently inhibits mushroom tyrosinase with an IC50 value of 40 μM, and inhibits human tyrosinase by 25-35% at 100 μM[1].
Decapeptide-12 (100 μM, 7 days) leads to 43% reduction in melanin content in melanocytes with no effect on cell proliferation[1].
Decapeptide-12 (peptide P4, 0-400 μM) inhibits the monophenolase reaction with an IC50 value of 123 μM[2].
Decapeptide-12 interact with tyrosinase with a Kd value of 61.1 μM[2].
Decapeptide-12 (100 μM, 72 h) increases transcription of SIRT1, SIRT3, SIRT6, and SIRT7 with reduced cytotoxicity in human neonatal keratinocyte progenitors[3].
Decapeptide-12 (0-1 mM, 72 h) reduces Phytohemagglutinin (PHA)-stimulated PBMC cells proliferation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Phytohemagglutinin (PHA)-stimulated PBMC cells
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Concentration:0, 0.025, 0.05, 0.1, 0.3, 1 mM
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Incubation Time:72 h
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Result:Reduced cell proliferation by 28% at 0.05 mM and 54% at 0.1 mM.
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Cell Line:Human neonatal keratinocyte progenitors
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Concentration:3, 10, 30, 50, 100, 300, 500, 1000 μM
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Incubation Time:72 h
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Result:Increased transcription of SIRT1 by 141% relative to untreated cells, increased SIRT3, SIRT6 and SIRT7 by 121%, 147% and 95%, respectively.
Chemical Information
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CAS No. 137665-91-9
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Appearance Solid
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Molecular Weight 1395.52
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Formula KS3WY3
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Color White to off-white
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Sequence Shortening
YRSRKYSSWY
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 100 mg/mL (71.66 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. [Content Brief]
[2]. Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.7166 mL | 3.5829 mL | 7.1658 mL | 17.9145 mL |
| 5 mM | 0.1433 mL | 0.7166 mL | 1.4332 mL | 3.5829 mL | |
| 10 mM | 0.0717 mL | 0.3583 mL | 0.7166 mL | 1.7914 mL | |
| 15 mM | 0.0478 mL | 0.2389 mL | 0.4777 mL | 1.1943 mL | |
| 20 mM | 0.0358 mL | 0.1791 mL | 0.3583 mL | 0.8957 mL | |
| 25 mM | 0.0287 mL | 0.1433 mL | 0.2866 mL | 0.7166 mL | |
| 30 mM | 0.0239 mL | 0.1194 mL | 0.2389 mL | 0.5971 mL | |
| 40 mM | 0.0179 mL | 0.0896 mL | 0.1791 mL | 0.4479 mL | |
| 50 mM | 0.0143 mL | 0.0717 mL | 0.1433 mL | 0.3583 mL | |
| 60 mM | 0.0119 mL | 0.0597 mL | 0.1194 mL | 0.2986 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Decapeptide-12 Related Classifications
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