Sodium Channel
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Sodium Channel Inhibitors
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Sodium Channel Agonists
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Sodium Channel Activators
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Sodium Channel Modulators
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Sodium Channel Ligands
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Sodium Channel Related Products (632)
Related Products (632)
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Benzonatate (PEGn)
0 ImagesCat. No.: HY-128418CAS No.: 32760-16-0Benzonatate (PEGn) is a unique non-narcotic antitussive agent that has sodium channel-blocking properties and anesthetic effects on the respiratory stretch receptors.
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Evenamide hydrochloride
0 ImagesCat. No.: HY-17612ACAS No.: 1092977-06-4Synonyms: NW-3509 hydrochlorideEvenamide hydrochloride is an orally available voltage-gated sodium channel (VGSC) blocker (Ki=0.4 μM) for the research of schizophrenia. Evenamide hydrochloride shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
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Bisaramil
0 ImagesCat. No.: HY-119092CAS No.: 89194-77-4Bisaramil is an orally active antiarrhythmic agent. Bisaramil exerts concentration dependent inhibitory effect on PMA-stimulated free radical generation and prolonged the time lag concentration dependently.
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Vinpocetine-d5
0 ImagesCat. No.: HY-13295SCAS No.: 2734920-39-7Vinpocetine-d5 is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.
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Mebeverine hydrochloride (Standard)
0 ImagesMebeverine (hydrochloride) (Standard) is the analytical standard of Mebeverine (hydrochloride). This product is intended for research and analytical applications. Mebeverine hydrochloride, a β-phenylethylamine derivative, is a musculotropic agent that potently blocks intestinal peristalsis. Mebeverine directly blocks voltage-operated sodium channels and inhibits intracellular calcium accumulation.
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GX-585
0 ImagesCat. No.: HY-167852CAS No.: 2098540-08-8GX-585 is a sulfonamide analog that acts as a Nav1.7 channel inhibitor, demonstrating analgesic activity in treating neuropathic pain and inflammation.
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Cofirasersen sodium
0 ImagesCat. No.: HY-139786ASynonyms: ION-827359 sodiumCofirasersen sodium is designed to reduce the expression of ENaC in the lung. ENaC is a sodium transport channel and believed to be hyperactive in cystic fibrosis, which is caused by mutations in the cystic fibrosis transmembrane regulator gene.
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Brompheniramine (Standard)
0 ImagesCat. No.: HY-B0480ARCAS No.: 86-22-6Synonyms: (±)-Brompheniramine (Standard)Brompheniramine (Standard) is the analytical standard of Brompheniramine. This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[4].
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Sodium Channel inhibitor 4
0 ImagesSodium Channel inhibitor 4 is a sodium channel inhibitor.
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Eslicarbazepine Acetate-d3
0 ImagesCat. No.: HY-W744263CAS No.: 2512192-54-8Eslicarbazepine Acetate-d3 is the deuterium labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
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PA1
0 ImagesCat. No.: HY-125667CAS No.: 1620951-72-5Synonyms: Photoamiloride-1PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively.
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Eleclazine
0 ImagesSynonyms: GS-6615Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias.
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JNJ-26990990
0 ImagesCat. No.: HY-12155CAS No.: 877316-38-6JNJ-26990990 is a broad-spectrum antiepileptic agent with oral activity. JNJ-26990990 can inhibit voltage-gated Na+ channels and N-type Ca2+ channels, but has a very weak inhibitory effect on human carbonic anhydrase-II (IC50 = 110 μM).
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Dichlorobenzamil
0 ImagesDichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits 45Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC50 = 18 μM). Dichlorobenzamil can also block K+ channels and voltage-sensitive Ca2+ channels.
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Denzimol hydrochloride
0 ImagesCat. No.: HY-105059ACAS No.: 77234-90-3Denzimol hydrochloride is an orally active anticonvulsant agent. Denzimol hydrochloride inhibits cytochrome P450, and interacts with benzodiazepine receptors. Denzimol hydrochloride selectively antagonizes tonic components of Metrazol-induced seizures in rats and mice. Denzimol hydrochloride can be used for the research of epilepsy and convulsions.
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PF-05150122
0 ImagesCat. No.: HY-128794CAS No.: 1235406-00-4PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential.
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KT 2-230
0 ImagesCat. No.: HY-106731CAS No.: 134296-41-6KT 2-230 is a sodium channel and calcium channel blocker with anti-inflammation effects.
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NaPi2b-IN-1
0 ImagesCat. No.: HY-142957CAS No.: 1453116-06-7NaPi2b-IN-1 is a potent and orally active inhibitor of sodium-dependent phosphate transport protein 2b (NaPi2b) with an IC50 of 64 nM. NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. NaPi2b-IN-1 has the potential for the research of hyperphosphatemia.
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ASIC-IN-1
0 ImagesCat. No.: HY-147391CAS No.: 308088-10-0ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.
