PF-05150122
PF-05150122 is a novel potent and selective human Nav1.7 channel blocker with the activity of inhibiting human pain signaling. PF-05150122 exhibited favorable biopharmacokinetic parameters in microdose studies, providing a basis for exploring its application in acute or chronic pain inhibition. The pharmacokinetic model of PF-05150122 predicted that at the corresponding oral dose, it could effectively reduce the 50% inhibitory concentration (IC50) of Nav1.7, demonstrating its inhibitory potential.
For research use only. We do not sell to patients.
- CAS No.: 1235406-00-4
- Formula: C24H21ClN6O3S2
- Molecular Weight:541.04
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1235406-00-4
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Molecular Weight 541.04
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Formula C24H21ClN6O3S2
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SMILES
N#CC1=CC(S(=O)(NC2=CSC=N2)=O)=CC=C1OC3=C(C4=CC=NN4C5CN(C5)CC)C=C(Cl)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-05150122 Related Classifications
HY-128794 Related Classifications
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