ASIC-IN-1
ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.
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- CAS. Nr.: 308088-10-0
- Formel: C23H25N3O2
- Molecular Weight:375.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: < 10 µM (acid sensing ion channel)[1]
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:150-180 g male Sprague-Dawley rats[1]
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Dosage:50 mg/kg
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Administration:I.p.
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Result:Blocked acute tonic pain induced by formalin injection in the paw.
Chemical Information
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CAS. Nr. 308088-10-0
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Molecular Weight 375.46
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Formel C23H25N3O2
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SMILES
CC1=NC2=CC=CC=C2C(N3CCN(CC(C4=CC=C(OC)C=C4)=O)CC3)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Two-electrode voltage clamp in Xenopus oocytes
Two-electrode voltage clamp measures whole-oocyte membrane current from Xenopus oocytes expressing exogenous ion channels, receptors, or transporters; one intracellular microelectrode senses membrane voltage, and the second injects current so the amplifier can hold the membrane at command voltages while recording the compensating current as the functional readout. The method is suited to Xenopus oocytes because their large size supports microinjection and intracellular electrode impalement, but the large membrane area can limit voltage-clamp speed and accuracy, especially for large or fast currents.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ASIC-IN-1 Related Classifications
HY-147391 Related Classifications
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