2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. ASIC-IN-1

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity.

For research use only. We do not sell to patients.

ASIC-IN-1 Chemical Structure

ASIC-IN-1 Chemical Structure

CAS No. : 308088-10-0

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Description

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1].

IC50 & Target

IC50: < 10 µM (acid sensing ion channel)[1]
In Vivo

ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 150-180 g male Sprague-Dawley rats[1]
Dosage: 50 mg/kg
Administration: I.p.
Result: Blocked acute tonic pain induced by formalin injection in the paw.
Molecular Weight

375.46

Formula

C23H25N3O2
CAS No.
SMILES

CC1=NC2=CC=CC=C2C(N3CCN(CC(C4=CC=C(OC)C=C4)=O)CC3)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ASIC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASIC-IN-1308088-10-0Sodium ChannelNa channelsNa+ channelspain intensityInhibitorinhibitorinhibit

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