TAM Receptor Degrader

PROTAC Axl Degrader 2 is an orally active and selective AXL PROTAC degrader with dual activities of AXL kinase inhibition and AXL protein degradation. PROTAC Axl Degrader 2 induces cytoplasmic vacuolization, excessive macropinosome production, oncosis, H-Ras activation, and Rac1-dependent non-apoptotic cell death. PROTAC Axl Degrader 2 inhibits the proliferation and migration of cancer cells, and also suppresses the growth of tumor cell xenografts under in vivo conditions. PROTAC Axl Degrader 2 can be used in research related to breast cancer.

PROTAC Axl Degrader 1 is an orally active PROTAC degrader targeting the AXL receptor tyrosine kinase, with an IC₅₀ of 0.92 μM against human targets. PROTAC Axl Degrader 1 induces cytoplasmic vacuolization, methuosis (macropinocytosis-induced cell death), excessive macropinosome production, and Rac1 activation. PROTAC Axl Degrader 1 inhibits the proliferation and migration of cancer cells. PROTAC Axl Degrader 1 can be used in breast cancer-related research.