2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Apolipoprotein

Apolipoprotein

Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III. Specific apolipoproteins function in the regulation of lipoprotein metabolism through their involvement in the transport and redistribution of lipids among various cells and tissues, through their role as cofactors for enzymes of lipid metabolism, or through their maintenance of the structure of the lipoprotein particles.

Apolipoprotein Isoform Specific Products:

Apolipoprotein Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171464A
    Lp(a)-IN-5 hydrochloride
    		Inhibitor 99.70%
    Lp(a)-IN-5 (Compound A) hydrochloride is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 hydrochloride inhibits the assembly of Apo(a) and ApoB proteins with an IC50 value of 0.41 nM. Lp(a)-IN-5 hydrochloride is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases.
    Lp(a)-IN-5 hydrochloride
  • HY-164740B
    Plozasiran sodium scrambled negative control
    		Inhibitor
    Plozasiran sodium scrambled negative control is the sequence scrambled negative control of Plozasiran sodium.
    Plozasiran sodium scrambled negative control
  • HY-P11502
    COG112
    COG112 is an antennapedia-linked apoE-mimetic peptide. COG112 attenuates induction of NO production, inhibits CXC chemokines KC and MIP-2. COG112 reduces nuclear translocation of NF-κB. COG112 inhibits phosphorylation of IκB-α and prevents the degradation of IκB-α. COG112 inhibits the inflammatory response to Citrobacter rodentium .
    COG112
  • HY-18778A
    Obicetrapib sodium
    		Inhibitor
    Obicetrapib (TA-8995; DEZ-001) sodium is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib sodium potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib sodium can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD).
    Obicetrapib sodium
  • HY-173323
    Lp(a)-IN-7
    		Inhibitor
    Lp(a)-IN-7 (example 1) is a lipoprotein (a) (Lp(a)) formation inhibitor with an IC50 of 2.51 nM in conditioned media containing apolipoprotein B (apoB) and apolipoprotein(a). Lp(a)-IN-7 can be used for the study of cardiovascular disease.
    Lp(a)-IN-7
  • HY-117555
    4010B-30
    		Activator
    4010B-30 is a upregulator of apolipoprotein A-I (ApoA-I). 4010B-30 regulates ApoA-I gene expression through activation of PPARγ. 4010B-30 promotes cholesterol efflux and ABCA1 expression. 4010B-30 protects against atherosclerotic lesion development in ApoE-/- mice.
    4010B-30
  • HY-153491B
    Olezarsen sodium scrambled negative control
    		Inhibitor
    Olezarsen sodium scrambled negative control is the sequence scrambled negative control of Olezarsen sodium.
    Olezarsen sodium scrambled negative control
  • HY-147425E
    Cy3 labled Zerlasiran sodium
    		Inhibitor
    Cy3 labled Zerlasiran sodium is a Cy3 labled Zerlasiran sodium (HY-147425A). Zerlasiran sodium is a siRNA targeting apolipoprotein A (ApoA). Zerlasiran sodium targets hepatic ApoA synthesis via RNA interference to degrade encoding mRNA. Zerlasiran sodium can be used for the research of atherosclerotic cardiovascular disease and elevated ApoA levels.
    Cy3 labled Zerlasiran sodium
  • HY-P10188
    apoB (4372-4392)
    		Inhibitor
    apoB (4372-4392) is a potent lipoprotein(a) assembly inhibitor, with an IC50 of 40 μM. apoB (4372-4392) can noncovalently bind to apolipoprotein(a) with high affinity.
    apoB (4372-4392)
  • HY-113510
    9(S)-HOTrE
    		Inducer 99.9%
    9(S)-HOTrE is a PPARα activator and an inducer of apolipoprotein A-I (apoA-I) mRNA expression. 9(S)-HOTrE upregulates the expression of PPARα target gene CPT1α. 9(S)-HOTrE can be used in the research of cardiovascular diseases.
    9(S)-HOTrE
  • HY-171464
    Lp(a)-IN-5
    		Inhibitor
    Lp(a)-IN-5 (Compound A) is an orally active lipoprotein (a) (Lp(a)) inhibitor. Lp(a)-IN-5 inhibits the assembly of Apo(a) and ApoB proteins with an IC50 value of 0.41 nM. Lp(a)-IN-5 is promising for research of diseases related to elevated plasma Lp(a) levels, such as cardiovascular diseases.
    Lp(a)-IN-5
  • HY-111346R
    1-Linoleoyl Glycerol (Standard)
    1-Linoleoyl Glycerol (Standard) is the analytical standard of 1-Linoleoyl Glycerol. This product is intended for research and analytical applications. 1-Linoleoyl glycerol is a LpPLA2 inhibitor. 1-Linoleoyl glycerol acts as a precursor for synthesizing various functional lipids, such as phospholipids. 1-Linoleoyl glycerol mitigates inflammation induced by Apolipoprotein CIII (reduction of IL-6).
    1-Linoleoyl Glycerol (Standard)
  • HY-179364
    PLTP-IN-1
    PLTP-IN-1 (cpd B) is a selective phospholipid transfer protein (PLTP) inhibitor with an IC50 of 1.6 μM. PLTP-IN-1 can block the phospholipid transfer mediated by PLTP and reduce the secretion of apolipoprotein B. PLTP-IN-1 has no effect on the level of triglycerides. PLTP-IN-1 can be used for the research of metabolic disease, such as hyperlipidemia.
    PLTP-IN-1
  • HY-RS19408
    Apoa4 Mouse Pre-designed siRNA Set A

    Apoa4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Components

    Apoa4 siRNA-1: 5 nmol (HPLC)

    Apoa4 siRNA-2: 5 nmol (HPLC)

    Apoa4 siRNA-3: 5 nmol (HPLC)

    siRNA Negative Control: 5 nmol (HPLC)

    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Apoa4 Mouse Pre-designed siRNA Set A
  • HY-RS19983
    Apoa2 Mouse Pre-designed siRNA Set A

    Apoa2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apoa2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Components

    Apoa2 siRNA-1: 5 nmol (HPLC)

    Apoa2 siRNA-2: 5 nmol (HPLC)

    Apoa2 siRNA-3: 5 nmol (HPLC)

    siRNA Negative Control: 5 nmol (HPLC)

    FAM-labeled siRNA Negative Control: 5 nmol (HPLC)

    GAPDH siRNA Positive Control: 5 nmol (HPLC)
    Apoa2 Mouse Pre-designed siRNA Set A
  • HY-103076R
    EZ-482 (Standard)
    EZ-482 (Standard) is the analytical standard of EZ-482 (HY-103076). This product is intended for research and analytical applications. EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas.
    EZ-482 (Standard)
Apolipoprotein Isoform Comparison

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