Atg8/LC3 Ligand
-
NLRP3 ATTEC degrader-1
0 ImagesCat. No.: HY-190873NLRP3 ATTEC degrader-1 is an autophagy-lysosomal degrader targeting NLRP3. NLRP3 ATTEC degrader-1 binds to NLRP3 and LC3 (NLRP3: Kd = 2.45 μM; LC3: Kd = 0.89 μM), tethering NLRP3 to autophagosomes for LC3-dependent lysosomal degradation. NLRP3 ATTEC degrader-1 shows sustained anti-inflammatory effects after washout, accompanied by durable NLRP3 reduction and cytokine suppression, and preferentially distributes to colon tissue after intraperitoneal administration. NLRP3 ATTEC degrader-1 can be used for research on inflammatory bowel disease.
-
TH152
0 ImagesCat. No.: HY-168347CAS No.: 1622917-95-6TH152 is a reversible, pan ligand for LC3/GABARAP with a KD of 2 µM. LC3/GABARAP is an autophagy associated protein.
