2. Signaling Pathways
  3. Cytoskeleton
  4. Claudin
  5. Claudin Antagonist

Claudin Antagonist

Claudin Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-P991200
    OM-7D3-B3
    		Antagonist
    OM-7D3-B3 is an antibody-based antiviral agent targeting the tight junction protein CLDN1 (Kd=4 nM). By binding to the first extracellular domain of CLDN1, OM-7D3-B3 disrupts the formation of the CLDN1-CD81 co-receptor complex, thereby effectively inhibiting the entry of hepatitis C virus (HCV). OM-7D3-B3 not only prevents de novo and chronic HCV infections in humanized liver chimeric mice and uPA-SCID mice transplanted with human livers, but also exhibits favorable safety with no toxic effects observed. OM-7D3-B3 serves as a critical tool for research on HCV infection mechanisms and antiviral drug development.