Disulfidptosis Inhibitor

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.

DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.

DL-Dithiothreitol-d₆ is the deuterated form of DL-Dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond.

DL-Dithiothreitol-d₁₀ is the deuterated form of DL-Dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-Dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.

DL-Dithiothreitol-d₁₀-1 is the deuterated form of DL-dithiothreitol. DL-Dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-Dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond.