2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Early 2 Factor (E2F)
  5. Early 2 Factor (E2F) Degrader

Early 2 Factor (E2F) Degrader

Early 2 Factor (E2F) Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-175397
    Dth
    		Degrader
    Dth (DFHBI-thalidomide) is an RNA aptamer-based PROTAC degrader. Dth can degrade a variety of endogenous proteins (such as mCherry, p50, p65 and E2F1) by replacing the 3′ module on the RNA scaffold with the RNA aptamer corresponding to the target protein. Dth upregulates IκB-α and Bax, and downregulates Bcl-2 and VEGF. Dth generates green fluorescence upon binding to the Broccoli RNA aptamer, enabling the tracing of RNA scaffolds. Dth can be used in cancer-related research.