2. Signaling Pathways
  3. GPCR/G Protein
  4. Hydroxycarboxylic Acid Receptor (HCAR)
  5. HCAR1 Isoform
  6. HCAR1 Agonist

HCAR1 Agonist

HCAR1 Agonists (2):

Cat. No. Product Name Effect Purity
  • HY-W016868
    3-Chloro-5-hydroxybenzoic acid
    		Agonist 99.54%
    3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity.
  • HY-W015560
    3,5-Dihydroxybenzoic acid
    		Agonist 99.98%
    3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active.