2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Large Tumor Suppressor (LATS)
  5. Large Tumor Suppressor (LATS) Activator

Large Tumor Suppressor (LATS) Activator

Large Tumor Suppressor (LATS) Activators (2):

Cat. No. Product Name Effect Purity
  • HY-N8847
    α-Ionone
    		Activator
    α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro.
  • HY-175247
    DDO-4033
    		Activator 99.11%
    DDO-4033 is a SPOP inhibitor (IC50 = 16.9 μM, Kd = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research.