Oxidative Phosphorylation Inducer
-
PDK1-IN-6
0 ImagesCat. No.: HY-190664PDK1-IN-6 is a PDK1 inhibitor (IC50 = 0.06 μM) and also inhibits PDK4 catalytic activity. PDK1-IN-6 inhibits HSP90 ATPase activity. PDK1-IN-6 reduces intracellular lactate accumulation, dissipates mitochondrial membrane potential, and induces Apoptotic cell death. PDK1-IN-6 shifts metabolism from glycolysis to oxidative phosphorylation and increases cellular oxygen consumption. PDK1-IN-6 exhibits anticancer activity against pancreatic cancer.
