Plasminogen/Plasmin Activator
-
Tenecteplase
0 ImagesCat. No.: HY-108845CAS No.: 191588-94-0Synonyms: TNK-tPATenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke.
-
Orniplabin
0 ImagesCat. No.: HY-122311CAS No.: 733805-92-0Synonyms: SMTP-7Orniplabin (SMTP-7) is a plasminogen modulator with a human EC50 of 65 μM. Orniplabin enhances the activation of plasminogen by plasminogen activators and increases the binding capacity of plasminogen to fibrin. Orniplabin elevates plasma levels of plasmin-α2-antiplasmin complex in vivo. Orniplabin is also a soluble epoxide hydrolase (sEH) inhibitor that prevents the hydrolysis and inactivation of anti-inflammatory epoxy fatty acids in vivo, exerting anti-inflammatory effects. Orniplabin inhibits the Cterm-EH and Nterm-phos of sEH with IC50 values of 23 μM and 6 μM, respectively. Orniplabin can be used in research related to pulmonary embolism and thrombotic stroke.
