Steroid Sulfatase
Steroid Sulfatase
Steroid sulfatase (STS) is a glycosylated protein with an apparent molecular weight of about 63–73 kDa. STS catalyzes the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids. STS can cleave estrone sulfate (E1S) and DHEA sulfate (DHEAS). STS is a potential target for the treatment of hormone-dependent diseases[1].
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Steroid Sulfatase Related Products (27)
Related Products (27)
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Steroid sulfatase/17β-HSD1-IN-5
0 ImagesCat. No.: HY-155010CAS No.: 3033655-07-8Steroid sulfatase/17β-HSD1-IN-5 is a irreversible inhibitor of steroid sulfatase (STS) .Steroid sulfatase/17β-HSD1-IN-5 is a reversible and selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), with IC50s of 43 nM and 6.2μM for 17β-HSD1 and 17β-HSD2, respectively. Steroid sulfatase/17β-HSD1-IN-5 can be used for metabolic disease (especially for endometriosis) research.
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Steroid sulfatase-IN-5
0 ImagesCat. No.: HY-155233Steroid sulfatase-IN-5 (compound 10b) is a steroid sulfatase (STS) inhibitor (IC50: 0.32 nM). Steroid sulfatase-IN-5 inhibits T-47D cell proliferation with an IC50 of 35.7 μM. Steroid sulfatase-IN-5 can be used for research of breast cancer.
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Steroid sulfatase/17β-HSD1-IN-1
0 ImagesCat. No.: HY-151199CAS No.: 2990549-70-5Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases.
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mGluR1 activator-1
0 ImagesCat. No.: HY-174987mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s.
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Steroid sulfatase/17β-HSD1-IN-4
0 ImagesCat. No.: HY-151202CAS No.: 2990549-94-3Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases.
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Dinordrin
0 ImagesCat. No.: HY-123420CAS No.: 64675-08-7Synonyms: Dinordrin IDinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels.
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Steroid sulfatase-IN-11
0 ImagesCat. No.: HY-181408CAS No.: 3075596-38-9Steroid sulfatase-IN-11 is a steroid sulfatase inhibitor, which functionally inhibits steroid sulfatase activity, reducing the enzyme's ability to hydrolyze steroid sulfates. Steroid sulfatase-IN-11 can be used for the research of hormone-dependent cancers.
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