Succinate Dehydrogenase
Succinate Dehydrogenase (SDH), also known as electron transport chain complex II, is a vital enzyme involved in both the citric acid cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone in the electron transport chain, which is essential for ATP generation and mitochondrial function. In eukaryotes, SDH is composed of four subunits (SDHA-D), localized to the inner mitochondrial membrane, while in prokaryotes, it is found in the cytoplasmic membrane. SDH deficiency can lead to an abnormal accumulation of succinate, contributing to age-related organ degeneration in tissues expressing SUCNR1. Elevated succinate levels have been linked to skeletal diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. This highlights the importance of SDH in maintaining cellular homeostasis and preventing metabolic disorders[1][2][3].
References:
- [1]. Zhao Y, et al. Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol. 2020 Sep 14;26(34):5074-5089. [Content Brief]
- [2]. Matlac DM, et al. Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas. Front Endocrinol (Lausanne). 2021 Mar 12;12:589451. [Content Brief]
- [3]. Moosavi B, et al. The assembly of succinate dehydrogenase: a key enzyme in bioenergetics. Cell Mol Life Sci. 2019 Oct;76(20):4023-4042. [Content Brief]
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Succinate Dehydrogenase Related Products (63)
Related Products (63)
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Antibodies (1)
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SDH-IN-45
0 ImagesCat. No.: HY-181610CAS No.: 3112883-32-3SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC50 of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold.
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SDH-IN-34
0 ImagesCat. No.: HY-178457SDH-IN-34 is a Succinate Dehydrogenase inhibitor with antifungal activity. SDH-IN-34 can be used for the research of infection.
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SDH-IN-30
0 ImagesCat. No.: HY-178050SDH-IN-30 (Compound 7m) is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.34 μM. SDH-IN-30 has potent antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 s of 0.004 and 0.028 μg/mL. SDH-IN-30 also has remarkable protective and curative efficacies against R. solani and significantly inhibits S. sclerotiorum growth on oilseed rape leaves by damaging the fungal cell structure. SDH-IN-30 can be used for fungal infections like rice sheath blight (RSB) and sclerotinia stem rot (SSR) research.
