Succinate Dehydrogenase

Succinate Dehydrogenase (SDH), also known as electron transport chain complex II, is a vital enzyme involved in both the citric acid cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone in the electron transport chain, which is essential for ATP generation and mitochondrial function. In eukaryotes, SDH is composed of four subunits (SDHA-D), localized to the inner mitochondrial membrane, while in prokaryotes, it is found in the cytoplasmic membrane. SDH deficiency can lead to an abnormal accumulation of succinate, contributing to age-related organ degeneration in tissues expressing SUCNR1. Elevated succinate levels have been linked to skeletal diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. This highlights the importance of SDH in maintaining cellular homeostasis and preventing metabolic disorders^[1]^[2]^[3].

References:

[1]. Zhao Y, et al. Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol. 2020 Sep 14;26(34):5074-5089. [Content Brief]

[2]. Matlac DM, et al. Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas. Front Endocrinol (Lausanne). 2021 Mar 12;12:589451. [Content Brief]

[3]. Moosavi B, et al. The assembly of succinate dehydrogenase: a key enzyme in bioenergetics. Cell Mol Life Sci. 2019 Oct;76(20):4023-4042. [Content Brief]

Succinate Dehydrogenase Related Products (53)
Antibodies (1)

By Effects:	Inhibitors (49) Substrates (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-44178S

Diethyl butylmalonate-d₉	Inhibitor	98%
Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease.

HY-176140

Succinate dehydrogenase-IN-9	Inhibitor
Succinate dehydrogenase-IN-9 (Compound Iik) is a succinate dehydrogenase inhibitor (IC₅₀: 3.6 μM). Succinate dehydrogenase-IN-9 exhibits potent inhibitory activity against various fungal species (eg: inhibits S. sclerotiorum with an EC₅₀ value of 1.14 μg/mL. Succinate dehydrogenase-IN-9 enhances the nitrate reductase activity, thereby facilitating plant growth.

HY-172810

Succinate dehydrogenase-IN-8	Inhibitor
Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC₅₀=0.1843 mg/L), Botrytis cinerea (EC₅₀=0.4829 mg/L), and Sclerotinia sclerotiorum (EC₅₀=0.1349 mg/L).

HY-N7114

Chloramphenicol succinate	Substrate
Chloramphenicol succinate is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC₅₀ of 1.585 nM. Chloramphenicol succinate serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate exerts a significant inhibitory effect on colitis. Chloramphenicol succinate can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease.

HY-159486

SDH-IN-18	Inhibitor
SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L.

HY-172362

SDH-IN-22	Inhibitor
SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC₅₀ of 0.5 mg/L.

HY-158321

SDH-IN-15	Inhibitor
SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.

HY-172363

Succinate dehydrogenase-IN-6	Inhibitor
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL).

HY-162776

Succinate dehydrogenase-IN-3	Inhibitor
Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity.

HY-169965

Succinate dehydrogenase-IN-4	Inhibitor
Succinate dehydrogenase-IN-4 (Compound 4b) is the inhibitor for succinate dehydrogenase with an IC₅₀ of 3.38 μM. Succinate dehydrogenase-IN-4 exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare with EC₅₀ of 16.33 μM and 18.06 μM.

HY-172777

SDH-IN-25	Inhibitor
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC₅₀ = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control.

HY-161504

SDH-IN-14	Inhibitor
SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC₅₀=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane.

HY-185574

Enpyracymid	Inhibitor
Enpyracymid is a succinate dehydrogenase inhibitor (SDHI) fungicide with fungicidal activity against fungal. It can be used in studies related to Fusarium head blight (FHB).

HY-159481

SDH-IN-17	Inhibitor
SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC₅₀=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research.

HY-B2011R

Flutolanil (Standard)	Inhibitor
Flutolanil (Standard) is the analytical standard of Flutolanil (HY-B2011). This product is intended for research and analytical applications. Flutolanil is a succinate dehydrogenase complex inhibitor and fungicide. Flutolanil blocks electron transfer between the redox center of succinate dehydrogenase and coenzyme Q, inhibits mycelial oxygen consumption, and suppresses mycelial growth. Flutolanil induces acute and sublethal toxicity in zebrafish at different life stages. Flutolanil can be used in studies on plant disease control.

HY-181346

SDH-IN-44	Inhibitor
SDH-IN-44 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 12.5 μg/mL against Alternaria solani. SDH-IN-44 exhibits antifungal activity and inhibits fungal mycelial growth. SDH-IN-44 is applicable to research related to fungal infections.

HY-174831

SDH-IN-28	Inhibitor
SDH-IN-28 is a succinate dehydrogenase inhibitor with an IC₅₀ value of 2.65 mg/L. SDH-IN-28 demonstrates broad-spectrum fungicidal efficacy, with EC₅₀ values of 0.21 (Valsa mali), 0.95 (Botrytis cinerea), 0.64 (Rhizoctonia solani), 1.33 (Fusarium graminearum), and 0.66 mg/L (Gaeumannomyces graminis). SDH-IN-28 effectively prevents V. mali infection in apples.

HY-174456

Succinate dehydrogenase-IN-10	Inhibitor
Succinate dehydrogenase-IN-10 (Compound B5) is a RsSDH (Succinate dehydrogenase of R. solani) inhibitor with an IC₅₀ of 0.12 μM. Succinate dehydrogenase-IN-10 exhibits antifungal activity against R. solani (EC₅₀ of 0.002 μg/mL) and P. pachyrhizi.

HY-173021

Succinate dehydrogenase-IN-7	Inhibitor
Succinate dehydrogenase-IN-7 (Compound 2f) is a Succinate dehydrogenase inhibitor (IC₅₀ = 2.51 μM). Succinate dehydrogenase-IN-7 has fungicidal activity.

HY-183722

SDH-IN-46	Inhibitor
SDH-IN-46 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 1.21 μM. SDH-IN-46 disrupts fungal respiration via mitochondrial respiratory chain enzyme targeting and exhibits broad-spectrum antifungal activity. SDH-IN-46 exhibits substantial protective effects against S. sclerotiorum on oilseed rape leaves, Rhizoctonia solani on rice leaves, and Valsa mali on apple fruits.

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Succinate Dehydrogenase

Succinate Dehydrogenase Related Products (53)

Antibodies (1)

Succinate Dehydrogenase Related Products (53):