Thiamine monochloride
Based on 2 publication(s) in Google Scholar
Thiamine monochloride (Vitamin B1) is an essential vitamin that plays an important role in cellular production of energy from ingested food and enhances normal neuronal actives.
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- Reinheit : 99.96%
- CAS. Nr.: 59-43-8
- Formel: C12H17ClN4OS
- Molecular Weight:300.81
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-16637
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HY-B0456
RiboflavinVitamin B2 -
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HY-B0430
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HY-B0143
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HY-B0315
Vitamin B12Endogenous Metabolite -
HY-B0511
BiotinVitamin B7 -
HY-B1328
PyridoxinePyridine Derivative -
HY-15398
Vitamin D3Vitamin -
HY-B0166
L-Ascorbic acidAntioxidant -
HY-N0682
Pyridoxine hydrochloridePyridine Derivative -
HY-A0100R
Thiamine monochloride (Standard)Neuronal Effect Enhancer
Publications Citing Use of MedChemExpress (MCE) Thiamine monochloride
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Biologische Aktivität
Beschreibung
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
Thiamine levels in the blood of homozygous KO and KI mice feed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compared to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a thiamine-restricted diet (thiamine: 0.60 mg/100 g food), blood thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compared to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. Notably, thiamine concentration in brain homogenate decreased steadily in KO and KI mice fed a thiamine-restricted diet (thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compared to WT (3.65±1.02 nmol/g wet weight), before the mice presented an phenotype of disease[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 59-43-8
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Appearance Solid
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Molecular Weight 300.81
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Formel C12H17ClN4OS
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Color White to off-white
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SMILES
CC1=C(CCO)SC=[N+]1CC2=CN=C(C)N=C2N.[Cl-]
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Synonyms
Vitamin B1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Immunity
Flavin adenine dinucleotide is an endogenous suppressor for cytosolic DNA and RNA sensors to modulate innate immunity. [Abstract]2026 Jul 13:S1074-7613(26)00261-X. PMID: 42442359 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Lösungsmittel & Löslichkeit
In Vitro:
H2O : ≥ 100 mg/mL (332.44 mM)
DMSO : 1 mg/mL (3.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 100 mg/mL (332.44 mM); Clear solution
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.3244 mL | 16.6218 mL | 33.2436 mL | 83.1089 mL |
| H2O | 5 mM | 0.6649 mL | 3.3244 mL | 6.6487 mL | 16.6218 mL |
| 10 mM | 0.3324 mL | 1.6622 mL | 3.3244 mL | 8.3109 mL | |
| 15 mM | 0.2216 mL | 1.1081 mL | 2.2162 mL | 5.5406 mL | |
| 20 mM | 0.1662 mL | 0.8311 mL | 1.6622 mL | 4.1554 mL | |
| 25 mM | 0.1330 mL | 0.6649 mL | 1.3297 mL | 3.3244 mL | |
| 30 mM | 0.1108 mL | 0.5541 mL | 1.1081 mL | 2.7703 mL | |
| 40 mM | 0.0831 mL | 0.4155 mL | 0.8311 mL | 2.0777 mL | |
| 50 mM | 0.0665 mL | 0.3324 mL | 0.6649 mL | 1.6622 mL | |
| 60 mM | 0.0554 mL | 0.2770 mL | 0.5541 mL | 1.3851 mL | |
| 80 mM | 0.0416 mL | 0.2078 mL | 0.4155 mL | 1.0389 mL | |
| 100 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.8311 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thiamine monochloride Related Classifications
HY-A0100 Related Classifications
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