1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

Valecobulin (Synonyms: CKD-516)

Cat. No.: HY-13598
Handling Instructions

Valecobulin (CKD516), a valine prodrug of (S516) and a vascular disrupting agent (VDA), is a potent beta-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

For research use only. We do not sell to patients.

Valecobulin Chemical Structure

Valecobulin Chemical Structure

CAS No. : 1188371-47-2

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Valecobulin (CKD516), a valine prodrug of (S516) and a vascular disrupting agent (VDA), is a potent beta-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].

IC50 & Target

Beta-tubulin polymerization[1].

In Vivo

The size change of the tumor in VX2 liver tumor-bearing rabbits is significantly smaller in the Valecobulin (CKD516)( 5, 9, or 12 mg/m2, i.v.)- treated group than in control group[2].

Animal Model: VX2 liver tumor-bearing rabbits (Male New Zealand White rabbits weighing between 2.5 and 3.5 kg)[2].
Dosage: Dissolved in 5 mL of saline at a dose of 5, 9, or 12 mg/m2 of body surface area.
Administration: Intravenous injection once.
Result: The size change of the tumors was significantly smaller in the treated group than in control group.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8636 mL 9.3179 mL 18.6359 mL
5 mM 0.3727 mL 1.8636 mL 3.7272 mL
10 mM 0.1864 mL 0.9318 mL 1.8636 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

536.60

Formula

C₂₆H₂₈N₆O₅S

CAS No.

1188371-47-2

SMILES

CC(C)[[email protected]](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Valecobulin
Cat. No.:
HY-13598
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Valecobulin

Cat. No.: HY-13598