1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Valecobulin

Valecobulin (Synonyms: CKD-516)

Cat. No.: HY-13598
Handling Instructions

Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

For research use only. We do not sell to patients.

Valecobulin Chemical Structure

Valecobulin Chemical Structure

CAS No. : 1188371-47-2

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Description

Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors[1][2].

IC50 & Target

β-tubulin polymerization[1].

In Vivo

Valecobulin (5 mg/kg; intraperitoneal injection; administered on days 2, 6, 10, and 14; male BALB/C nu/nu mice) treatment shows markedly antitumor efficacy in various human tumor xenograft models[1].

Animal Model: Male BALB/C nu/nu mice (5-6 weeks of age) with HCT-116 or HCT-15 cells[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; administered on days 2, 6, 10, and 14
Result: Had shown marked antitumor efficacy in various human tumor xenograft models.
Clinical Trial
Molecular Weight

536.60

Formula

C₂₆H₂₈N₆O₅S

CAS No.

1188371-47-2

SMILES

CC(C)[[email protected]](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ValecobulinCKD-516CKD516CKD 516Microtubule/TubulinS516VDAβ-tubulinantitumorprodrugInhibitorinhibitorinhibit

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Valecobulin
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HY-13598
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