1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. ABT-418 hydrochloride

ABT-418 hydrochloride 

Cat. No.: HY-105170B Purity: 99.53%
Handling Instructions

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

For research use only. We do not sell to patients.

ABT-418 hydrochloride Chemical Structure

ABT-418 hydrochloride Chemical Structure

CAS No. : 147388-83-8

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

IC50 & Target

nAChRs[1][2]

In Vivo

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]
Dosage: 0.6 mg/kg
Administration: Intraperitoneal injection; once daily; for two weeks
Result: Effectively improved spatial memory.
Molecular Weight

202.68

Formula

C₉H₁₅ClN₂O

CAS No.

147388-83-8

SMILES

CN1[[email protected]](C2=CC(C)=NO2)CCC1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References
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Keywords:

ABT-418ABT418ABT 418nAChRNicotinic acetylcholine receptorsChCAnAChRsAlzheimer'sdiseaseInhibitorinhibitorinhibit

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ABT-418 hydrochloride
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HY-105170B
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