2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. ABT-418 hydrochloride

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

For research use only. We do not sell to patients.

ABT-418 hydrochloride Chemical Structure

ABT-418 hydrochloride Chemical Structure

CAS No. : 147388-83-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in Water USD 132 In-stock
Solid
5 mg USD 120 In-stock
10 mg USD 200 In-stock
25 mg USD 400 In-stock
50 mg USD 600 In-stock
100 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

ABT-418 hydrochloride Related Antibodies

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  • Purity & Documentation

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Description

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

IC50 & Target

nAChRs[1][2]
In Vivo

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]
Dosage: 0.6 mg/kg
Administration: Intraperitoneal injection; once daily; for two weeks
Result: Effectively improved spatial memory.
Molecular Weight

202.68

Formula

C9H15ClN2O
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

CN1[C@H](C2=CC(C)=NO2)CCC1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 11.9 mg/mL (58.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9339 mL 24.6694 mL 49.3389 mL
5 mM 0.9868 mL 4.9339 mL 9.8678 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (493.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9339 mL 24.6694 mL 49.3389 mL 123.3472 mL
5 mM 0.9868 mL 4.9339 mL 9.8678 mL 24.6694 mL
10 mM 0.4934 mL 2.4669 mL 4.9339 mL 12.3347 mL
15 mM 0.3289 mL 1.6446 mL 3.2893 mL 8.2231 mL
20 mM 0.2467 mL 1.2335 mL 2.4669 mL 6.1674 mL
25 mM 0.1974 mL 0.9868 mL 1.9736 mL 4.9339 mL
30 mM 0.1645 mL 0.8223 mL 1.6446 mL 4.1116 mL
40 mM 0.1233 mL 0.6167 mL 1.2335 mL 3.0837 mL
50 mM 0.0987 mL 0.4934 mL 0.9868 mL 2.4669 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ABT-418 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-418147388-83-8ABT418ABT 418nAChRNicotinic acetylcholine receptorsChCAnAChRsAlzheimer'sdiseaseInhibitorinhibitorinhibit

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