2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ABT-418

ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder.

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ABT-418

ABT-418 Chemical Structure

CAS No. : 147402-53-7

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Description

ABT-418 is a selective neuronal nicotinic acetylcholine receptor ligand with activity in improving spatial memory. ABT-418 administered before training can significantly reduce the spatial discrimination deficit caused by ventricular damage. ABT-418 is considered to be a potential treatment for attention deficit disorder[1].

Cellular Effect
Cell Line Type Value Description References
IMR-32 EC50
64 μM
Compound: 1 (ABT-418)
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
Concentration required to elicit ganglionic receptors measured using [86Rb+] flux functional assay in a human neuroblastoma-derived IMR-32 cell line
[PMID: 9022806]
IMR-32 EC50
64 μM
Compound: ABT-418
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
Tested for functional activity against neuronal nicotinic acetylcholine receptor(nAChR) expressed in IMR-32 cells using isotopic rubidium efflux assay.
10.1016/S0960-894X(97)10080-4
PC-12 EC50
214 μM
Compound: 10
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
[PMID: 9435889]
TE-671 EC50
411 μM
Compound: ABT-418
Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
Tested for functional activity against alpha-1 neuronal nicotinic acetylcholine receptor(nAChR) expressed in TE671 cells using isotopic rubidium efflux assay.
10.1016/S0960-894X(97)10080-4
Molecular Weight

166.22

Formula

C9H14N2O
CAS No.
SMILES

CN1[C@H](C2=CC(C)=NO2)CCC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ABT-418 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-418147402-53-7ABT418ABT 418Endogenous MetaboliteInhibitorinhibitorinhibit

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