147388-83-8
147388-83-8
Chemical Structure
ABT-418 hydrochloride
- CAS No.: 147388-83-8
- Formula:C9H15ClN2O
- Molecular Weight:202.68
IUPAC Name: (S)-3-methyl-5-(1-methylpyrrolidin-2-yl)isoxazole hydrochloride
InChIKey: VOXHERKWAIEJQF-QRPNPIFTSA-N
SMILES: CN1[C@H](C2=CC(C)=NO2)CCC1.Cl
Biological Activity: ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
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ABT-418 hydrochloride | 98.00% | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease. | ||||||||||||||||||||
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ABT-418 hydrochloride (Standard) | ≥98% | ABT-418 hydrochloride (Standard) is the analytical standard of ABT-418 hydrochloride (HY-105170B). This product is intended for research and analytical applications. ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-14314ABT-418 -
Similarity Score 0.68
HY-203084(S)-6-Methylnicotine -
Similarity Score 0.63
HY-W0129373-Hydroxymethyl-5-methylisoxazole -
Similarity Score 0.62
HY-14318Altinicline -
Similarity Score 0.62
HY-W698445α-Nicotine -
Similarity Score 0.62
HY-W0416765-Methylisoxazol-3-amine -
Similarity Score 0.62
HY-138953AEpiboxidine hydrochloride -
Similarity Score 0.61
HY-138953Epiboxidine -
Similarity Score 0.60
HY-W653822(2'S)-Nicotine 1-oxide -
Explore the MedChemAI to find more analogs
References
- [1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [Content Brief]
- [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5. [Content Brief]
