Aluminum oxide
Based on 1 Customer Validation
Aluminum oxide is a nanoparticulate carrier and adjuvant.Aluminum oxide elicits antibody production against non-immunogenic haptens when coupled to them in mice and rabbits. Aluminum oxide functions in eliciting antibodies from non-immunogenic haptens.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 1344-28-1
- Formula: Al2H2O3
- Molecular Weight:103.98
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Aluminum oxide (12 mg particle mass; 16 h incubation) particles exhibit passive protein adsorption capacity for BSA, as detected by SDS-PAGE[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aluminum oxide (0.20 mg; intramuscular; initial dose with/without complete Freund’s adjuvant; boosts with/without incomplete Freund’s adjuvant at 21-day intervals) elicits selective antibody responses against atrazine-related compounds in rabbits, with Freund’s adjuvant co-administration altering cross-reactivity profiles[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (H-2d) (female)[1]
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Dosage:1 mg (Al₂O₃-hapten conjugate); 100 µg (Al₂O₃-aprotinin-hapten conjugate)
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Administration:i.p.; every 2 weeks; 5 doses
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Result:Achieved a mean serum absorbance (λ 490 nm) of 2.26 for Al₂O₃-2d (hapten conjugate); achieved a mean absorbance of 2.68 for Al₂O₃-aprotinin-2d; yielded IC50 values of 1182 ng/mL (300 nm Al₂O₃-2d) and 1372 ng/mL (40 nm Al₂O₃-2d) via competitive ELISA.
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Animal Model:New Zealand white (female)[1]
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Dosage:0.20 mg
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Administration:intramuscular; initial dose with/without complete Freund’s adjuvant; boosts with/without incomplete Freund’s adjuvant at 21-day intervals
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Result:Elicited cross-reactivity values of 80% for propazine, 29% for simazine, 17% for deethylatrazine, <0.01% for prometryn, and 5% for deisopropylatrazine (relative to atrazine = 100%) for Al₂O₃-2d (hapten conjugate).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1344-28-1
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Appearance Solid
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Molecular Weight 103.98
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Formula Al2H2O3
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Color White to off-white
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SMILES
O=[Al][Al](O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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