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Aluminum oxide is a nanoparticulate carrier and adjuvant.Aluminum oxide elicits antibody production against non-immunogenic haptens when coupled to them in mice and rabbits. Aluminum oxide functions in eliciting antibodies from non-immunogenic haptens.

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Aluminum oxide

Aluminum oxide Chemical Structure

CAS No. : 1344-28-1

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Aluminum oxide Related Antibodies

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Description

Aluminum oxide is a nanoparticulate carrier and adjuvant.Aluminum oxide elicits antibody production against non-immunogenic haptens when coupled to them in mice and rabbits. Aluminum oxide functions in eliciting antibodies from non-immunogenic haptens[1].

In Vitro

Aluminum oxide (12 mg particle mass; 16 h incubation) particles exhibit passive protein adsorption capacity for BSA, as detected by SDS-PAGE[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aluminum oxide Related Antibodies
In Vivo

Aluminum oxide (1 mg, 100 µg; i.p.; every 2 weeks; 5 doses) acts as an adjuvant/carrier to elicit antibody responses against haptens, with Freund’s adjuvant co-administration enhancing antibody sensitivity (lower IC50) and mean absorbance values[1].
Aluminum oxide (0.20 mg; intramuscular; initial dose with/without complete Freund’s adjuvant; boosts with/without incomplete Freund’s adjuvant at 21-day intervals) elicits selective antibody responses against atrazine-related compounds in rabbits, with Freund’s adjuvant co-administration altering cross-reactivity profiles[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (H-2d) (female)[1]
Dosage: 1 mg (Al₂O₃-hapten conjugate); 100 µg (Al₂O₃-aprotinin-hapten conjugate)
Administration: i.p.; every 2 weeks; 5 doses
Result: Achieved a mean serum absorbance (λ 490 nm) of 2.26 for Al₂O₃-2d (hapten conjugate); achieved a mean absorbance of 2.68 for Al₂O₃-aprotinin-2d; yielded IC50 values of 1182 ng/mL (300 nm Al₂O₃-2d) and 1372 ng/mL (40 nm Al₂O₃-2d) via competitive ELISA.
Animal Model: New Zealand white (female)[1]
Dosage: 0.20 mg
Administration: intramuscular; initial dose with/without complete Freund’s adjuvant; boosts with/without incomplete Freund’s adjuvant at 21-day intervals
Result: Elicited cross-reactivity values of 80% for propazine, 29% for simazine, 17% for deethylatrazine, <0.01% for prometryn, and 5% for deisopropylatrazine (relative to atrazine = 100%) for Al₂O₃-2d (hapten conjugate).
Clinical Trial
Molecular Weight

103.98

Formula

Al2H2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[Al][Al](O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 99%

SDS (393 KB)

COA (255 KB)

Handling Instructions (2659 KB)
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Aluminum oxide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aluminum oxide1344-28-1Biochemical Assay ReagentsEnvironmental PollutantsEnvironmental Contaminantshaptensaprotinin conjugatesatrazine-related compoundsInhibitorinhibitorinhibit

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