AMPA receptor modulator-3

Name: AMPA receptor modulator-3
Brand: MedChemExpress
SKU: HY-122150
Rating: 4.5 (1 reviews)

Cat. No.: HY-122150 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

AMPA receptor modulator-3 is an allosteric AMPA receptor modulator (EC₅₀: 4.4 μM). AMPA receptor modulator-3 can be used in the research of mammalian nervous system, such as learning and memory.

For research use only. We do not sell to patients.

AMPA receptor modulator-3 Chemical Structure

CAS No. : 211311-39-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 330	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

AMPA receptor modulator-3 (Compound 5e) shows an EC₅₀ value of 4.4 μM for potentiation of responses mediated by 100 μM L-glutamate in HEK-293 cells expressing iGluR4 flip^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

335.44

Formula

C₁₈H₂₂FNO₂S

CAS No.

211311-39-6

Appearance

Solid

Color

White to off-white

SMILES

CC(S(=O)(NCC(C1=CC=C(C2=CC=CC=C2F)C=C1)C)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (745.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9812 mL	14.9058 mL	29.8116 mL
5 mM	0.5962 mL	2.9812 mL	5.9623 mL
10 mM	0.2981 mL	1.4906 mL	2.9812 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (265 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Kasper Harpsøe, et al. Prediction of the binding mode of biarylpropylsulfonamide allosteric AMPA receptor modulators based on docking, GRID molecular interaction fields and 3D-QSAR analysis. J Mol Graph Model. 2008 Jan;26(5):874-83. https://pubmed.ncbi.nl [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9812 mL	14.9058 mL	29.8116 mL	74.5290 mL
	5 mM	0.5962 mL	2.9812 mL	5.9623 mL	14.9058 mL
	10 mM	0.2981 mL	1.4906 mL	2.9812 mL	7.4529 mL
	15 mM	0.1987 mL	0.9937 mL	1.9874 mL	4.9686 mL
	20 mM	0.1491 mL	0.7453 mL	1.4906 mL	3.7264 mL
	25 mM	0.1192 mL	0.5962 mL	1.1925 mL	2.9812 mL
	30 mM	0.0994 mL	0.4969 mL	0.9937 mL	2.4843 mL
	40 mM	0.0745 mL	0.3726 mL	0.7453 mL	1.8632 mL
	50 mM	0.0596 mL	0.2981 mL	0.5962 mL	1.4906 mL
	60 mM	0.0497 mL	0.2484 mL	0.4969 mL	1.2421 mL
	80 mM	0.0373 mL	0.1863 mL	0.3726 mL	0.9316 mL
	100 mM	0.0298 mL	0.1491 mL	0.2981 mL	0.7453 mL