Anti-Mouse LAG-3 Antibody (C9B7W)
Based on 1 Customer Validation
Anti-Mouse LAG-3 Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 Antibody (C9B7W) can enhance CD4+ T cell function and exert anti-tumor effects without blocking the interaction between LAG-3 and MHCII. Anti-Mouse LAG-3 Antibody (C9B7W) can be used for research on cancer such as head and neck squamous cell carcinoma (HNSCC).
For research use only. We do not sell to patients.
- Purity: 99%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG1 kappa
Mouse
LAG-3
Anti-Mouse LAG-3 Antibody (C9B7W) (10 mg/kg, i.p., on day 7, 10 and 14) exhibits significant anti-tumor activity in female A/J mice bearing SA1N tumors[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nitrochin (100 µg/mL) induced C57BL/6 mice (6 weeks)[2]
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Dosage:10 mg/kg, combined with PD-1 mAb
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Administration:Intraperitoneal injection (i.p.), once every 3 days, for 14 and 21 days
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Result:Inhibited tumor growth in 57.1% of mice.
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Animal Model:1.0×106 SA1N cells injected female A/J mice[3]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), on day 7, 10 and 14
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Result:Significantly inhibited tumor volume.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay, Research in vivo
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse LAG-3 Antibody (C9B7W)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[2]. Wang X, et al. Resistance to anti-LAG-3 plus anti-PD-1 therapy in head and neck cancer is mediated by Sox9+ tumor cells interaction with Fpr1+ neutrophils. Nat Commun. 2025 Apr 28;16(1):3975. [Content Brief]
[3]. Thudium K, et al. Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res. 2022 Oct 4;10(10):1175-1189. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse LAG-3 Antibody (C9B7W) Related Classifications
HY-P99141 Related Classifications
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