Lag3 - lymphocyte-activation gene 3 Gene

Also Known as Ly66; CD223; LAG-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16768

Summary

Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]

Lag3 Products (1)

mRNA Protein Name
NM_008479.2 NP_032505.1 lymphocyte activation gene 3 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class II protein binding IDA
IDA: Inferred from direct assay
12209638 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
30580966 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
12209638 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell activation IDA
IDA: Inferred from direct assay
12421911 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12421911 MGI
involved in cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
12209638 MGI
acts upstream of interleukin-2 production IDA
IDA: Inferred from direct assay
12421911 MGI
acts upstream of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
8602528 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
8602528 MGI
acts upstream of or within negative regulation of T cell activation IDA
IDA: Inferred from direct assay
12421911 MGI
involved in negative regulation of T cell activation IDA
IDA: Inferred from direct assay
12209638 MGI
acts upstream of or within negative regulation of interleukin-2 production IDA
IDA: Inferred from direct assay
12421911 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
15485628 MGI
involved in plasmacytoid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
19201841 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
8602528 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
8602528 MGI
involved in regulation of immune response IDA
IDA: Inferred from direct assay
30580966 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8602528 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
17245433 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphocyte activation gene 3 protein

  • activation-induced cytidine deaminase-linked autoimmunity protein

  • aida

Lag3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lag3 Q61790 Fgl1 Mus musculus Q71KU9
BLI
30580966
Intra
Lag3 Q61790 Fgl1 Mus musculus Q71KU9
Array
30580966
Cross
Lag3 Q61790 FGL1 Homo sapiens Q08830
Array
30580966
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Lag3 Proteins

Cat. No. Product Name Accession Purity
HY-P73843 LAG-3 Protein, Mouse (HEK293, Fc) Q61790/NP_032505.1 (S23-L442) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73844 LAG-3 Protein, Mouse (HEK293) Q61790 (G24-L442) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78720 LAG-3 Protein, Mouse (HEK293, His) Q61790 (G24-L442) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (16)
Cat. No. Product Name Effect
Purity Phase
HY-P99156 Relatlimab 98.00% Phase 4
HY-P99573 Tebotelimab 99.52% Phase 3
HY-P99613 Favezelimab 97.79% Phase 3
HY-P99617 Fianlimab 99.04% Phase 3
HY-P990968 Alcestobart 98.383% Phase 3
HY-P99027 Ieramilimab ≥99.0% Phase 2
HY-P990750 Negalstobart 96.89% Phase 2
HY-P990700 Tobemstomig 97.06% Phase 2
HY-P99736 Miptenalimab 97.04% Phase 2
HY-P990046 Tuparstobart 97.65% Phase 2
HY-P990740 Fanastomig 95.478% Phase 2
HY-P991300 GSK2831781 Inhibitor / Phase 2
HY-P991605 HLX26 Inhibitor / Phase 2
HY-P991301 IMP-761 Inhibitor 97.24% Phase 1
HY-P99354 Bavunalimab 99.408% Phase 1
HY-P991303 TQB-2223 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-144088 ZYF0033 Inhibitor 98.82% Unkown
HY-172930 PVTX-405 97.07% Unkown
HY-176813 LAG-3 Hit II Inhibitor 99.58% Unkown
HY-162811 LAG-3 biner 1 97.08% Unkown
HY-164308 SA-15-P Inhibitor 99.9% Unkown
HY-122081 CPI-644 Inhibitor / Unkown
HY-145240 eIF4E-IN-1 Inhibitor / Unkown
HY-149916 A2AR-antagonist-1 Antagonist 96.68% Unkown
HY-176814 LAG-3-IN-1 Inhibitor / Unkown
HY-178320 LAG-3-IN-2 Inhibitor / Unkown
HY-179060 LAG-3 PROTAC-1 Degrader / Unkown
HY-179061 LAG-3 degrader 1 Degrader / Unkown
HY-179071 DAPK1 ligand-1 Degrader / Unkown
HY-180900 Z3071585108 Ligand / Unkown
HY-181685 LAGi-DEL Inhibitor / Unkown
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / Unkown
HY-P10837 LAG-3 cyclic peptide inhibitor 12 Inhibitor / Unkown
HY-RS07492 LAG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16686 Lag3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23121 Lag3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99141 Anti-Mouse LAG-3 Antibody (C9B7W) Inhibitor 99% Unkown
HY-P99922 Encelimab Inhibitor 95.25% Unkown
HY-P990976 Brivestobart 99.198% Unkown
HY-P990912 Cugrastomig 98.46% Unkown
HY-P991297 AM0003 Inhibitor / Unkown
HY-P991298 DNV-3 Inhibitor / Unkown
HY-P991299 ENUM006 Inhibitor / Unkown
HY-P991302 KL-A289 Inhibitor / Unkown
HY-P992075 Anti-Bovine LAG-3 Antibody (2D8) Inhibitor / Unkown
HY-P992254 Anti-LAG-3 Antibody (BAP050) Inhibitor / Unkown
HY-P992352 ES005 / Unkown
HY-P992461 SHR-1802 Inhibitor / Unkown
HY-P990204 Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) Inhibitor / Unkown
HY-P992156 Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lag3 NCBI NCBI:3902