Fianlimab
Based on 1 Customer Validation
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.04%
- CAS. Nr.: 2126132-98-5
- Molecular Weight:146.46 kDa
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biologische Aktivität
Human IgG4 kappa
Human
LAG3/CD223
Fianlimab inhibits the interaction between LAG-3 and MHC II, blockes the binding of MHC II-positive human Raji B cells and murine A20 B cells to HEK293/hLAG-3 cells, with EC50s of 4.2 nM and 7.1 nM, respectively[2].
Fianlimab restores T cell activity (EC50=4.7 nM), promotes the secretion of IFNγ, and enhances antitumor immune responses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse MC38.Ova colon cancer cell xenograft model[2]
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Dosage:5-25 mg/kg
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Administration:ip, twice a week for 2 weeks
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Result:Inhibited tumor growth, increased the concentrations of IFNγ, TNFα, and IL10 in serum and spleen.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
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Flow cytometric analysis of 1X1050 Jurkat cells with Fianlimab (HY-P99617, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS. Nr. 2126132-98-5
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Appearance Liquid
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Molecular Weight 146.46 kDa
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Color Colorless to light yellow
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SMILES
[Fianlimab]
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Synonyms
REGN3767
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Versand
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)